Dextroamphetamine modulates the response of the human amygdala
Dextroamphetamine modulates the response of the human amygdala
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DOI：
10.1016/s0893-133x(02)00373-1
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发表时间：
2002-12-01
影响因子：
7.6
通讯作者：
Weinberger, DR
中科院分区：
文献类型：
--
作者：
Hariri, AR;Mattay, VS;Weinberger, DR
安非他明是一种有效的单胺能激动剂，对人类的情绪行为有明显的影响，包括恐惧和焦虑的产生。最近的动物研究已经证明了单胺，特别是多巴胺，在调节杏仁核反应的重要性，杏仁核是一个关键的大脑区域，参与感知恐惧和威胁性刺激，并产生适当的生理和行为反应。我们已经探索了安非他明对人类的焦虑作用反映了药物对杏仁核活动的影响的可能性。在一项双盲安慰剂对照研究中，功能性磁共振成像显示，在对愤怒和恐惧的面部表情进行知觉处理时，苯丙胺增强了杏仁核的反应。我们的研究结果提供了第一个证据的一个特定的神经基板的安非他明的焦虑作用，并与杏仁核多巴胺能激活的动物模型是一致的。(C)2002年美国神经精神药理学学会。出版社：Elsevier Science Inc.
Amphetamine, a potent monoaminergic agonist, has pronounced effects on emotional behavior in humans, including the generation of fear and anxiety. Recent animal studies have demonstrated the importance of monoamines, especially dopamine, in modulating the response of the amygdala, a key brain region involved in the perception of fearful and threatening stimuli, and the generation of appropriate physiological and behavioral responses. We have explored the possibility that the anxiogenic effect of amphetamine in humans reflects the drug's influence on the activity of the amygdala. In a double-blind placebo controlled study, fMRI revealed that dextroamphetamine potentiated the response of the amygdala during the perceptual processing of angry and fearful facial expressions. Our results provide the first evidence of a specific neural substrate for the anxiogenic effects of amphetamine and are consistent with animal models of dopaminergic activation of the amygdala. (C) 2002 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.