Intrinsic Signal Imaging of Deprivation-Induced Contraction of Whisker Representations in Rat Somatosensory Cortex
Intrinsic Signal Imaging of Deprivation-Induced Contraction of Whisker Representations in Rat Somatosensory Cortex
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DOI：
10.1093/cercor/bhn085
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发表时间：
2009-02-01
期刊：
影响因子：
3.7
通讯作者：
Feldman, Daniel E.
中科院分区：
文献类型：
--
作者：
Drew, Patrick J.;Feldman, Daniel E.
在经典的感觉皮层地图可塑性中，被剥夺或未充分使用的输入在皮层感觉地图内收缩，而备用输入扩展。备用输入的扩展优先发生在附近的皮质柱代表时间相关的备用输入，这表明扩展涉及基于相关性的学习规则在跨柱突触。目前尚不清楚是否剥夺表征合同在类似的各向异性的方式，这将涉及类似的学习规则和可塑性的网站。我们短暂剥夺了20日龄大鼠的D排胡须，这样每个被剥夺的胡须都剥夺了（D排）和幸免（C排和E排）的邻居。内源性信号光学成像显示，D-行剥夺减弱和收缩的D-行晶须在L2/3的躯体感觉（S1）皮层的功能表示。southwhisker表示没有加强或扩大，表明D-行剥夺选择性地从事地图可塑性的抑郁成分。收缩被剥夺的胡须表示是空间均匀的，从幸免和被剥夺的邻居相等撤回。单单位的电生理记录证实了这些结果，并表现出显着减弱的反应剥夺晶须层2/3的S1，和适度减弱L4。观察到的各向同性收缩的剥夺晶须表示在D-行剥夺是一致的可塑性，而不是跨柱，突触。
In classical sensory cortical map plasticity, the representation of deprived or underused inputs contracts within cortical sensory maps, whereas spared inputs expand. Expansion of spared inputs occurs preferentially into nearby cortical columns representing temporally correlated spared inputs, suggesting that expansion involves correlation-based learning rules at cross-columnar synapses. It is unknown whether deprived representations contract in a similar anisotropic manner, which would implicate similar learning rules and sites of plasticity. We briefly deprived D-row whiskers in 20-day-old rats, so that each deprived whisker had deprived (D-row) and spared (C- and E-row) neighbors. Intrinsic signal optical imaging revealed that D-row deprivation weakened and contracted the functional representation of deprived D-row whiskers in L2/3 of somatosensory (S1) cortex. Spared whisker representations did not strengthen or expand, indicating that D-row deprivation selectively engages the depression component of map plasticity. Contraction of deprived whisker representations was spatially uniform, with equal withdrawal from spared and deprived neighbors. Single-unit electrophysiological recordings confirmed these results, and showed substantial weakening of responses to deprived whiskers in layer 2/3 of S1, and modest weakening in L4. The observed isotropic contraction of deprived whisker representations during D-row deprivation is consistent with plasticity at intracolumnar, rather than cross-columnar, synapses.