Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline: Executive Summary
Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline: Executive Summary
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DOI：
10.1093/cid/ciaa241
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发表时间：
2020-08-15
影响因子：
11.8
通讯作者：
Winthrop, Kevin L.
中科院分区：
文献类型：
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作者：
Daley, Charles L.;Iaccarino, Jonathan M.;Winthrop, Kevin L.
非结核分枝杆菌（NTM）代表超过190个种和亚种，其中一些可以在所有年龄段的人类中产生疾病，并且可以影响肺和肺外部位。本指南重点关注由最常见的NTM病原体引起的成人肺部疾病（无囊性纤维化或人类免疫缺陷病毒感染），如缓慢生长的NTM中的鸟分枝杆菌复合体、堪萨斯分枝杆菌和Xenopi分枝杆菌以及快速生长的NTM中的结核分枝杆菌。由国际领先的呼吸道医学和传染病学会（ATS、ERS、ESCMID、IDSA）精心挑选了一个专家小组，其中包括肺部医学、传染病和临床微生物学、实验室医学和患者宣传方面的专家。围绕22个皮科（人群、干预、对照、结局）问题中的每一个进行了系统评价，并使用GRADE（建议评估、制定和评价分级）方法制定、撰写和分级建议。提供了31条关于NTM肺病治疗的循证建议。本指南旨在供护理NTM肺病患者的医疗保健专业人员使用，包括传染病和肺病专家。
Nontuberculous mycobacteria (NTM) represent over 190 species and subspecies, some of which can produce disease in humans of all ages and can affect both pulmonary and extrapulmonary sites. This guideline focuses on pulmonary disease in adults (without cystic fibrosis or human immunodeficiency virus infection) caused by the most common NTM pathogens such as Mycobacterium avium complex, Mycobacterium kansasii, and Mycobacterium xenopi among the slowly growing NTM and Mycobacterium abscessus among the rapidly growing NTM. A panel of experts was carefully selected by leading international respiratory medicine and infectious diseases societies (ATS, ERS, ESCMID, IDSA) and included specialists in pulmonary medicine, infectious diseases and clinical microbiology, laboratory medicine, and patient advocacy. Systematic reviews were conducted around each of 22 PICO (Population, Intervention, Comparator, Outcome) questions and the recommendations were formulated, written, and graded using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach. Thirty-one evidence-based recommendations about treatment of NTM pulmonary disease are provided. This guideline is intended for use by healthcare professionals who care for patients with NTM pulmonary disease, including specialists in infectious diseases and pulmonary diseases.