Effects of immunomodulatory cytokines on the presentation of tumor-associated antigens by epidermal Langerhans cells.
Effects of immunomodulatory cytokines on the presentation of tumor-associated antigens by epidermal Langerhans cells.
复制标题
免疫调节细胞因子对表皮朗格汉斯细胞呈递肿瘤相关抗原的影响。
DOI：
10.1111/1523-1747.ep12669018
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Granstein,RD
中科院分区：
文献类型：
--
作者：
Grabbe,S;Bruvers,S;Granstein,RD
皮肤抗原提呈细胞（APC）对肿瘤相关抗原的识别和提呈在建立有效的皮肤肿瘤防御机制中发挥重要作用。最近的数据表明，I-A+表皮细胞（朗格汉斯细胞）的能力，目前肿瘤相关抗原的诱导保护性肿瘤免疫和诱发迟发型超敏反应的小鼠梭形细胞肿瘤，S1509 a。此外，皮肤肿瘤附近的局部细胞因子微环境可以调节常驻表皮APC启动和/或引发针对初期皮肤肿瘤的保护性免疫的能力。本文综述了粒细胞-巨噬细胞/集落刺激因子（GM-CSF）、白细胞介素-1 α（IL-1 α）、肿瘤坏死因子-α（TNFα）、转化生长因子-β（TGFβ）和干扰素-γ（IFNγ）在表皮APC调节抗原提呈中的作用。我们的数据表明，这些细胞因子显着和差异修改表皮细胞的能力，目前肿瘤相关抗原，其效果不同方面诱导原发性免疫（致敏）或诱发继发性免疫反应。
The recognition and presentation of tumor-associated antigens by cutaneous antigen-presenting cells (APC) may play an important role in the establishment of effective defense mechanisms against newly emerging tumors in the skin. Recent data demonstrate the ability of I-A+epidermal cells (Langerhans cells) to present tumor-associated antigens for the induction of protective tumor immunity and elicitation of delayed-type hypersensitivity against the murine spindle cell tumor, S1509a. Furthermore, the local cytokine microenvironment in the vicinity of a cutaneous neoplasm may regulate the ability of resident epidermal APC to initiate and/or to elicit protective immunity against incipient cutaneous neoplasms. This article summarizes the effects of granulocyte-macrophage/colony-stimulating factor (GM-CSF), interleukin-lα (IL-lα), tumor necrosis factor-α (TNFα), transforming growth factor-β (TGFβ), and interferon-γ (IFNγ) on the modulation of antigen presentation by epidermal APC. Our data indicate that these cytokines significantly and differentially modify the ability of epidermal cells to present tumor-associated antigens and that their effects differ with regard to induction of primary immunity (sensitization) or elicitation of secondary immune responses.