Blastocyst transfer and gender: IVF versus ICSI
Blastocyst transfer and gender: IVF versus ICSI
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DOI：
10.1007/s10815-009-9337-3
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发表时间：
2009-08-01
影响因子：
3.1
通讯作者：
Bertheussen, Kjell
中科院分区：
文献类型：
--
作者：
Hentemann, Martha Agnes;Briskemyr, Siri;Bertheussen, Kjell
目的探讨新鲜体外受精（IVF）后新生儿移植后第5天性别比的差异。方法回顾性分析1995 - 1999年IVF/ICSI/FER治疗后的临床资料，结果在420例出生后第5天移植的婴儿中，有225名男性和195名女性婴儿。然而，单独ICSI后，30例为女性，21例为男性。将长期培养后性别比文献中的所有可用数据相加，男性出生与总出生的比率（0.545）与预期比率（0.515）存在显著差异（p=0.004）。结论体外受精第5天移植后出生的男性比预期的要多。然而，在我们的数据中比较IVF，ICSI和FER的亚组分析显示，ICSI和FER后出生的女性更多，这表明在这一领域需要进一步的研究。
Purpose To investigate the difference in sex ratio in our centre after day 5 embryo transfer among neonates delivered after fresh in vitro fertilization (IVF), fresh intra cytoplasmatic sperminjection (ICSI) and frozen embryo replacement (FER) compared to expected sex ratio in normal population.Methods Retrospective data after IVF/ICSI/FER therapy from 1995 - 2007 and data from the literature on similar subjects.Results Among a total of 420 births after day 5 transfer, there were 225 male and 195 female babies. However, after ICSI alone 30 were female and 21 male. Adding all available data from the literature on gender ratio after long term culture, the ratio of male births to total births (0.545) was significantly (p=0.004) different from the expected ratio (0.515)Conclusions It appears that significantly more males are born than expected after day 5 transfer in IVF. However, a subgroup analysis in our data comparing IVF, ICSI and FER revealed more females born after ICSI and FER, suggesting that further research is needed in this area.