Metabolic syndrome pandemic
Metabolic syndrome pandemic
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DOI：
10.1161/atvbaha.107.151092
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发表时间：
2008-04-01
影响因子：
8.7
通讯作者：
Grundy, Scott M.
中科院分区：
文献类型：
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作者：
Grundy, Scott M.
代谢综合征是一种多重危险因素，包括几个代谢源的危险相关因素。此外，除了血脂异常、高血压和高甘油血症外，该综合征还伴有促血栓形成状态和促炎症状态。患有代谢综合征的人患心血管疾病的风险基本上是没有代谢综合征的人的两倍。它进一步增加了2型糖尿病的风险约5倍。虽然一些研究者倾向于将风险因素分开用于临床管理，但其他研究者认为，识别具有风险因素聚集的个体提供了额外的有用信息来指导临床管理。特别是它关注肥胖和久坐不动的生活习惯，这是综合征的根源。这篇评论讨论了这种聚集现象在世界各地的普遍性。这似乎是适当的，因为肥胖症在几乎所有国家都越来越普遍。现有证据表明，在大多数国家，20%至30%的成年人口可以被描述为患有代谢综合征。在某些人群或部分人群中，患病率甚至更高。另一方面，在发展中国家的一些地区，年轻人占主导地位，流行率较低;但随着人口的日益富裕和老龄化，流行率无疑会上升。
The metabolic syndrome is a multiplex risk factor that consists of several risk correlates of metabolic origin. In addition, to dyslipidemia, hypertension, and hyperglycermia, the syndrome carries a prothrombotic state and a proinflammatory state. Persons with the metabolic syndrome are at essentially twice the risk for cardiovascular disease compared with those without the syndrome. It further raises the risk for type 2 diabetes by about 5-fold. Although some investigators favor keeping risk factors separate for purposes of clinical management, others believe that identifying individuals with an aggregation of risk factors provides additional useful information to guide clinical management. In particular it focuses attention on obesity and sedentary life habits that are the root of the syndrome. This review addresses the prevalence of this clustering phenomenon throughout the world. Such seems appropriate because of the increasing prevalence of obesity in almost all countries. The available evidence indicates that in most countries between 20% and 30% of the adult population can be characterized as having the metabolic syndrome. In some populations or segments of the population, the prevalence is even higher. On the other hand, in parts of developing world in which young adults predominate, the prevalence is lower; but with increasing affluence and aging of the population, the prevalence undoubtedly with rise.