Electroacupuncture-induced neural activation detected by use of manganese-enhanced functional magnetic resonance imaging in rabbits
Electroacupuncture-induced neural activation detected by use of manganese-enhanced functional magnetic resonance imaging in rabbits
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DOI：
10.2460/ajvr.2001.62.178
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发表时间：
2001-02-01
影响因子：
1
通讯作者：
Ho, LT
中科院分区：
文献类型：
--
作者：
Chiu, JH;Cheng, HC;Ho, LT
为探讨针刺对锰增强功能磁共振成像（manganeseenhancedfunctionalmagneticresonanceimaging，fMRI）神经活动的影响，阐明穴位刺激与脑激活的关系，采用新西兰白色兔40只，对电针足三里、阳陵泉穴的麻醉家兔进行了锰增强fMRI。图像采集在1.5T MRI临床扫描仪上进行，具有圆极化末端线圈。T1加权图像采集顺序如下：基线，甘露醇注射后，锰输液后，5和20分钟后开始EA.Results-Changes局灶性神经活动检测使用锰增强功能磁共振成像。刺激足三里5分钟可激活海马，而刺激阳陵泉5分钟可激活下丘脑、下丘脑和运动皮层。EA 20分钟后，激活的特异性变得不那么强。结论和临床意义--每个穴位都有相应的脑联系，刺激这些穴位会导致时间依赖性的神经激活。了解外周穴位刺激与中枢神经通路之间的联系，可以为针灸的临床应用提供有益的指导。
Objective-To investigate the effects of acupuncture on neural activity detected by use of manganese-enhanced functional magnetic resonance imaging (fMRI) and elucidate the relationship between somatic acupoint stimulation and brain activation.Animals-40 New Zealand White rabbits.Procedure-Manganese-enhanced fMRI was performed in anesthetized rabbits manipulated with electroacupuncture (EA) on Zusanli (ST-36) and Yanglingquan (GB-34) acupoints. Image acquisition was performed on a 1.5T superconductive clinical scanner with a circular polarized extremity coil. T1-weighted images were acquired sequentially as follows: baseline, after mannitol injection, after manganese infusion, and 5 and 20 minutes after initiation of EA.Results-Changes in focal neural activity were detected by use of manganese-enhanced fMRI. Stimulation on Zusanli (ST-36) for 5 minutes resulted in activation of the hippocampus, whereas stimulation on Yanglingquan (GB-34) resulted in activation of the hypothalamus, insula, and motor cortex. Activation became less specific after 20 minutes of EA. Furthermore, stimulation on ipsilateral acupoints led to bilateral brain activation.Conclusions and Clinical Relevance-Each acupoint has a corresponding cerebral linkage, and stimulation on these points resulted in time-dependent neural activation. Understanding the linkage between peripheral acupoint stimulation and central neural pathways may provide a useful guide for clinical applications of acupuncture.