Efficacy of Transsphenoidal Surgery on Endocrinological Status and Serum Chemistry Parameters in Dogs with Cushing's Disease
Efficacy of Transsphenoidal Surgery on Endocrinological Status and Serum Chemistry Parameters in Dogs with Cushing's Disease
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DOI：
10.1292/jvms.09-0367
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发表时间：
2010-04-01
影响因子：
1.2
通讯作者：
Tagawa, Masahiro
中科院分区：
文献类型：
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作者：
Hara, Yasushi;Teshima, Takahiro;Tagawa, Masahiro
本研究对25只库欣病犬经蝶窦手术（ISS）后4年内的内分泌和血清生化变化进行了前瞻性研究。25只狗库欣氏病是由切除的垂体组织诊断为垂体前叶的促肾上腺皮质激素腺瘤。在TSS之前，所有25例阻塞均显示高皮质醇血症。TSS后，ACTH刺激试验显示21只犬（84%）血清皮质醇浓度持续较低。此外，血清促甲状腺激素浓度依次下降，而血清T4浓度趋于增加，由于术后激素替代治疗，以避免继发性甲状腺功能减退。在血清化学的独奏会上。碱性磷酸酶（ALP）、丙氨酸氨基转移酶（ALT）和总胆固醇通常在库欣病中升高。本研究ALP。ALT和总胆固醇升高分别为23例（92%）、19例（76%）和20例（80%）。分别然而.术后这些浓度逐渐降低。术后1年血清ALP、6个月~ 2年血清ALT、4年血清总胆固醇水平均较术前显著下降。这些结果表明，TSS是一种有效的治疗犬库欣病和长期改善高皮质醇血症。而且。TSS可有效改善皮质醇增多症，如血清ALP浓度升高。ALT和总胆固醇。
Postoperative changes in endocrinological status and serum chemistry during the 4 years after transsphenoidal surgery (ISS) in 25 dogs with Cushing's disease were investigated in a prospective study. In all 25 dogs. Cushing's disease was diagnosed from resected pituitary tissues as a corticotroph adenoma in the anterior lobe of the pituitary. Prior to TSS, all 25 clogs showed hypercortisolemia. After TSS, the ACTH stimulation test showed continued low serum cortisol concentrations in 21 dogs (84%). In addition, the serum thyroid stimulating hormone concentrations decreased sequentially, while the serum T4 concentrations tended to increase due to the postoperative hormone substitution therapy utilized to avoid secondary hypothyroidism. In recital to serum chemistry. alkaline phosphatase (ALP), alanine aminotransferase (ALT) and total cholesterol are commonly increased in can Cushing's disease. In this study. ALP. ALT and total cholesterol were increased in 23 eases (92%), 19 cases (76%) and 20 cases (80%). respectively. However. postoperatively, these concentrations gradually decreased. The postoperative serum concentrations of ALP at I year, that of ALT at six months to 2 years and that of total cholesterol over the course of the 4 years decreased significantly compared with the concentrations before TSS. These results show that TSS is an effective treatment for canine Cushing's disease and for long-term improvement of hypercortisolemia. Moreover. TSS is effective in improvement or hypercortisolism, such as increased concentrations of serum ALP. ALT and total cholesterol.