Genetic Models in Applied Physiology. Functional genomics in the mouse: powerful techniques for unraveling the basis of human development and disease.
Genetic Models in Applied Physiology. Functional genomics in the mouse: powerful techniques for unraveling the basis of human development and disease.
复制标题
应用生理学中的遗传模型。
DOI：
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发表时间：
2003
影响因子：
3.3
通讯作者：
C. Bogue
中科院分区：
文献类型：
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作者：
C. Bogue
现在，小鼠和人类基因组的DNA序列都接近完整，下一个主要挑战将是确定这些基因中的每一个单独以及与基因组中其他基因组合时的功能。小鼠在生物学研究方面有着悠久而丰富的历史，许多人认为它是研究人类发育和疾病的模式生物。在过去的几年里，在染色体工程、诱变、突变定位和维持以及小鼠突变基因鉴定等技术的发展方面取得了令人兴奋的进展。在这篇简短的综述中，我们将沿着介绍这些强大的技术，以及它们在发育、生理和疾病研究中的应用。
Now that near-complete DNA sequences of both the mouse and human genomes are available, the next major challenge will be to determine how each of these genes functions, both alone and in combination with other genes in the genome. The mouse has a long and rich history in biological research, and many consider it a model organism for the study of human development and disease. Over the past few years, exciting progress has been made in developing techniques for chromosome engineering, mutagenesis, mapping and maintenance of mutations, and identification of mutant genes in the mouse. In this mini-review, many of these powerful techniques will be presented along with their application to the study of development, physiology, and disease.