SEIZURES IN ALZHEIMER'S DISEASE
SEIZURES IN ALZHEIMER'S DISEASE
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DOI：
10.1016/j.neuroscience.2014.11.051
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发表时间：
2015-02-12
期刊：
影响因子：
3.3
通讯作者：
Born, H. A.
中科院分区：
文献类型：
--
作者：
Born, H. A.
阿尔茨海默病（AD）增加了迟发性癫痫发作和神经元网络异常的风险。在更流行的散发性AD中，AD和癫痫发作的共同发生率升高。最近的证据表明，非惊厥性网络异常，包括癫痫发作和其他脑电图异常，可能比以前认为的更常见于患者。家族性AD患者癫痫发作的风险更高，在PSEN 1、PSEN 2或APP突变以及APP重复的患者中发现了癫痫发作。本文还对AD小鼠模型的癫痫发作和脑电图研究进行了综述。淀粉样蛋白-β（A β）肽已被确定为AD和癫痫发作之间的可能联系，虽然已知A β影响神经元活动，但全长淀粉样蛋白前体蛋白（APP）和其他APP裂解产物可能对皮质网络过度兴奋的发展和维持很重要。非惊厥性癫痫样活动，如持续时间较短但发生频率较高的癫痫发作或网络异常，可能导致AD特征性认知障碍，如遗忘性游荡。最后，审查讨论了最近的研究，使用抗癫痫药物，以挽救AD小鼠模型和人类患者的认知缺陷。了解癫痫样活动和AD之间的机制联系是一个越来越感兴趣的研究领域。进一步了解神经元过度兴奋和阿尔茨海默氏症之间的联系以及癫痫样活动在AD进展中的潜在作用将有利于改善治疗策略。(C)2014年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Alzheimer's disease (AD) increases the risk for late-onset seizures and neuronal network abnormalities. An elevated co-occurrence of AD and seizures has been established in the more prevalent sporadic form of AD. Recent evidence suggests that nonconvulsive network abnormalities, including seizures and other electroencephalographic abnormalities, may be more commonly found in patients than previously thought. Patients with familial AD are at an even greater risk for seizures, which have been found in patients with mutations in PSEN1, PSEN2, or APP, as well as with APP duplication. This review also provides an overview of seizure and electroencephalography studies in AD mouse models. The amyloid-beta (A beta) peptide has been identified as a possible link between AD and seizures, and while A beta is known to affect neuronal activity, the full-length amyloid precursor protein (APP) and other APP cleavage products may be important for the development and maintenance of cortical network hyperexcitability. Nonconvulsive epileptiform activity, such as seizures or network abnormalities that are shorter in duration but may occur with higher frequency, may contribute to cognitive impairments characteristic of AD, such as amnestic wandering. Finally, the review discusses recent studies using anti-epileptic drugs to rescue cognitive deficits in AD mouse models and human patients. Understanding the mechanistic link between epileptiform activity and AD is a research area of growing interest. Further understanding of the connection between neuronal hyperexcitability and Alzheimer's as well as the potential role of epileptiform activity in the progression of AD will be beneficial for improving treatment strategies. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.