Detection of passage and absorption of chicken egg yolk immunoglobulins in the gastrointestinal tract of pigs by use of enzyme-linked immunosorbent assay and fluorescent antibody testing.
Detection of passage and absorption of chicken egg yolk immunoglobulins in the gastrointestinal tract of pigs by use of enzyme-linked immunosorbent assay and fluorescent antibody testing.
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DOI：
10.2460/ajvr.1993.54.06.867
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发表时间：
1993-06
影响因子：
1
通讯作者：
H. Yokoyama;ROBERT C. Peralta;Sadako Sendo;Y. Ikemori;Y. Kodama
中科院分区：
文献类型：
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作者：
H. Yokoyama;ROBERT C. Peralta;Sadako Sendo;Y. Ikemori;Y. Kodama
新生猪血液中的鸡卵黄抗体与初乳抗体一样能被吸收和转移。蛋黄抗体在新生猪血清中的半衰期为1.85天。这比报道的猪血清中同源免疫球蛋白的半衰期(12至14天)要短。与初乳抗体相似，蛋黄抗体在出生后约34小时停止从肠道吸收卵黄免疫球蛋白，吸收率从出生起呈对数下降。蛋黄免疫球蛋白在胃肠道的吸收抑制时间为1.73小时，缩短了一半。蛋黄免疫球蛋白在高剂量给药时对猪实验性腹泻有保护作用，并可多次给药。给猪口服蛋黄免疫球蛋白未见不良反应。
Chicken egg yolk IgG can be absorbed and transferred as efficiently as colostral antibodies in the blood of neonatal pigs. Egg yolk IgG has a half-life of 1.85 days in newborn pig serum. This is shorter than the reported half-life (12 to 14 days) of homologous IgG in serum of pigs. Similar to colostral antibodies, egg yolk IgG absorption from intestine ceased at about 34 hours of age, after a logarithmic decrease in absorption rate from birth. Egg yolk IgG absorption inhibition time in the gastrointestinal tract took 1.73 hours to decrease by half. Egg yolk IgG was protective against experimentally induced diarrhea in pigs when it was administered at high dose, and multiple dosing was instituted. Adverse effects were not observed when chicken egg yolk IgG was administered orally to pigs.