Activation of hypolipidaemic drugs to acyl-coenzyme A thioesters.
Activation of hypolipidaemic drugs to acyl-coenzyme A thioesters.
复制标题
将降血脂药物激活为酰基辅酶 A 硫酯。
DOI：
10.1042/bj2390781
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
M. Morales
中科院分区：
文献类型：
--
作者：
M. Bronfman;L. Amigo;M. Morales
化合物具有CoA硫酯的特征的hypolipidaemic过氧化物酶体增殖剂氯贝酸，萘诺平和环丙贝特形成孵育的药物与大鼠肝微粒体组分，ATP和CoA。药物的反应性与其药理效力相关。据推测，这些化合物的活性物种是它们的酰基-CoA硫酯。
Compounds possessing the characteristics of CoA thioesters of the hypolipidaemic peroxisome proliferators clofibric acid, nafenopin and ciprofibrate were formed on incubation of the drugs with rat liver microsomal fractions, ATP and CoA. The reactivity of the drugs correlated with their pharmacological potency. It is proposed that the active species of these compounds are their acyl-CoA thioesters.