CYTOGENETIC FINDINGS IN 11 GASTRIC CARCINOMAS
CYTOGENETIC FINDINGS IN 11 GASTRIC CARCINOMAS
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DOI：
10.1016/0165-4608(93)90072-t
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发表时间：
1993-07-01
影响因子：
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通讯作者：
SOBRINHOSIMOES, M
中科院分区：
文献类型：
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作者：
SERUCA, R;CASTEDO, S;SOBRINHOSIMOES, M
我们描述了10个原发性胃腺癌和一个淋巴结转移的胃腺癌直接收获或短期体外培养后的细胞遗传学研究结果。所有病例均表现出数量不等的数量和/或结构克隆细胞遗传学畸变。2号和20号染色体的多体性是最常见的数目异常。在超过一半的病例中，分别观察到1、3、7和13号染色体重排。3号和13号染色体更常表现出结构细胞遗传学畸变。在5个肿瘤中，注意到6号染色体重排导致6 q的部分缺失（共同缺失区域6 q21 -22-->qter）。在我们的系列中观察到的复发标志物分别是3例和2例病例的i（8 q）和i（17 q）。双分钟（dmin）或均匀染色区（hsr）在三个肿瘤明显。与最近声称影响11 p13-p15的结构异常特别涉及胃癌相反，我们仅在两例病例中检测到该区域的重排。
We describe the results of the cytogenetic study of 10 primary adenocarcinomas of the stomach and one lymph node metastasis of a gastric adenocarcinoma after direct harvesting or short-term in vitro culture. All cases showed a variable number of numerical and/or structural clonal cytogenetic aberrations. Polysomy of chromosomes 2 and 20 were the most common numerical abnormalities. Rearrangements of chromosomes 1, 3, 7, and 13 were each observed in more than half the cases. Chromosomes 3 and 13 were the chromosomes more often exhibiting structural cytogenetic aberrations. In five tumors, rearrangements of chromosome 6 resulting in partial deletion of 6q were noted (common deleted region 6q21-22-->qter). The recurrent markers observed in our series were an i(8q) and an i(17q) in three and two cases, respectively. Double minutes (dmin) or homogeneously staining regions (hsr) were evident in three tumors. Contrary to the recent claim that structural abnormalities affecting 11p13-p15 were specifically involved in gastric cancer, we detected rearrangements of this region in only two cases.