Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants
Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants
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DOI：
10.1016/j.earlhumdev.2012.12.011
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发表时间：
2013-06-01
影响因子：
2.5
通讯作者：
Hara, Toshiro
中科院分区：
文献类型：
--
作者：
Inoue, Hirosuke;Ohga, Shouichi;Hara, Toshiro
背景：支气管肺发育不良（BPD）是一种主要发生在早产儿中的慢性肺部疾病。BPD的发病机制涉及早期炎症和肺重塑，目的：为了寻找BPD发生的新的预测指标，我们研究了先天性免疫介质中性粒细胞明胶酶相关脂质运载蛋白（NGAL）在早产儿血清中的水平。测定了52例无异常或遗传病的婴儿的参考水平。结果：无基础疾病的新生儿出生时血清NGAL水平的几何均数（95%CI）分别为32.4（22.1-47.5）、58.6（47.9-71.8）和126.2（99.0-168.7）ng/mL，孕周36周（GW），差异有统计学意义（P < 0.05）。
Background: Bronchopulmonary dysplasia (BPD) is a chronic lung disease mostly occurring in preterm infants. The pathogenesis of BPD involves early inflammation and remodeling of the premature lung.Aim: To search for the novel predictive marker of BPD development, we studied serum levels of neutrophil gelatinase-associated lipocalin (NGAL), an innate immune mediator, in preterm infants.Methods: Serum NGAL concentrations at birth were measured by enzyme-linked immunosorbent assay. The,reference levels were determined in 52 infants having no anomalies or inherited diseases. The levels and clinical variables were assessed in association with BPD.Results: Geometric means (95%CI) of serum NGAL levels at birth of infants having no underlying diseases were 32.4 (22.1-47.5), 58.6 (47.9-71.8), and 126.2 (99.0-168.7) ng/mL for 36 gestational weeks (GW), respectively (p