Mobilizing endogenous stem cells for retinal repair.
Mobilizing endogenous stem cells for retinal repair.
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DOI：
10.1016/j.trsl.2013.11.011
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Chen DF
中科院分区：
文献类型：
--
作者：
Yu H;Vu TH;Cho KS;Guo C;Chen DF
Irreversible vision loss is most often caused by the loss of function and subsequent death of retinal neurons, such as photoreceptor cells—the cells that initiate vision by capturing and transducing signals of light. One reason why retinal degenerative diseases are devastating is that, once retinal neurons are lost, they don't grow back. Stem cell-based cell replacement strategy for retinal degenerative diseases are leading the way in clinical trials of transplantation therapy, and the exciting findings in both human and animal models point to the possibility of restoring vision through a cell replacement regenerative approach. A less invasive method of retinal regeneration by mobilizing endogenous stem cells thus is highly desirable and promising for restoring vision. Although many obstacles remain to be overcome, the field of endogenous retinal repair is progressing at a rapid pace with encouraging results in recent years.
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