MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.
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DOI：
10.1084/jem.20081326
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发表时间：
2009-03-16
期刊：
影响因子：
--
通讯作者：
Sleckman BP
中科院分区：
文献类型：
--
作者：
Helmink BA;Bredemeyer AL;Lee BS;Huang CY;Sharma GG;Walker LM;Bednarski JJ;Lee WL;Pandita TK;Bassing CH;Sleckman BP
The Mre11–Rad50–Nbs1 (MRN) complex functions in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) at postreplicative stages of the cell cycle. During HR, the MRN complex functions directly in the repair of DNA DSBs and in the initiation of DSB responses through activation of the ataxia telangiectasia-mutated (ATM) serine-threonine kinase. Whether MRN functions in DNA damage responses before DNA replication in G0/G1 phase cells has been less clear. In developing G1-phase lymphocytes, DNA DSBs are generated by the Rag endonuclease and repaired during the assembly of antigen receptor genes by the process of V(D)J recombination. Mice and humans deficient in MRN function exhibit lymphoid phenotypes that are suggestive of defects in V(D)J recombination. We show that during V(D)J recombination, MRN deficiency leads to the aberrant joining of Rag DSBs and to the accumulation of unrepaired coding ends, thus establishing a functional role for MRN in the repair of Rag-mediated DNA DSBs. Moreover, these defects in V(D)J recombination are remarkably similar to those observed in ATM-deficient lymphocytes, suggesting that ATM and MRN function in the same DNA DSB response pathways during lymphocyte antigen receptor gene assembly.
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影响因子：
64.5
作者：
Buis J;Wu Y;Deng Y;Leddon J;Westfield G;Eckersdorff M;Sekiguchi JM;Chang S;Ferguson DO
通讯作者：
Ferguson DO
在发展ATM缺乏的B和T淋巴细胞中，体内编码关节形成的缺陷。
DOI：
10.1084/jem.20061460
发表时间：
2007-06-11
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
--
DOI：
10.4049/jimmunol.181.4.2620
发表时间：
2008-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bredemeyer AL;Huang CY;Walker LM;Bassing CH;Sleckman BP
通讯作者：
Sleckman BP
影响因子：
64.5
作者：
Barlow, C;Hirotsune, S;WynshawBoris, A
通讯作者：
WynshawBoris, A
影响因子：
30.8
作者：
Gatei, M;Young, D;Khanna, K
通讯作者：
Khanna, K