Omeprazole in the treatment of peptic ulcers resistant to H2‐receptor antagonist
Omeprazole in the treatment of peptic ulcers resistant to H2‐receptor antagonist
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奥美拉唑治疗对H2受体拮抗剂耐药的消化性溃疡
DOI：
10.1111/j.1365-2036.1990.tb00476.x
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发表时间：
1990
影响因子：
7.6
通讯作者：
M. Quina
中科院分区：
文献类型：
--
作者：
A. S. Guerreiro;B. Neves;M. Quina
30 名患有消化性溃疡的患者，对单用全剂量 H2 受体拮抗剂或随后使用其他抗溃疡药物连续治疗至少 8 周有耐药性，接受胃质子泵抑制剂奥美拉唑（40 mg）治疗，每天口服一次，持续长达 8 周。研究设计是非比较性和开放性的；通过内窥镜检查证实愈合。仅治疗2周后，23名十二指肠溃疡患者中有21名痊愈（91%），十二指肠溃疡和胃溃疡患者中有2名痊愈，幽门前溃疡患者中有3名痊愈。 4周后，所有十二指肠溃疡、2个胃溃疡中的1个和3个幽门前溃疡中的2个痊愈。再治疗一个月，胃溃疡就痊愈了，总体治愈率为 97%，在研究结束时只有一名患者（幽门前溃疡）未治愈。
Thirty patients with peptic ulcers resistant to at least 8 weeks of continuous therapy with full‐dose H2‐receptor antagonists alone or followed by other anti‐ulcer drugs, were treated with the gastric proton pump inhibitor omeprazole (40 mg), administered orally once daily for up to 8 weeks. The study design was non‐comparative and open; healing was verified by endoscopy. After only 2 weeks of treatment, 21 out of 23 (91%) duodenal ulcer patients were healed, as well as 2 out of 2 patients with both duodenal and gastric ulcer and 1 out of 3 patients with prepyloric ulcer. After 4 weeks, all duodenal ulcers, 1 out of 2 gastric ulcers and 2 out of 3 pre‐pyloric ulcers were healed. A further month of therapy healed the gastric ulcer to give an overall healing rate of 97% and leaving only one patient (pre‐pyloric ulcer) unhealed at the end of the study.