Passive smoking and pancreatic cancer in women: a prospective cohort study.
Passive smoking and pancreatic cancer in women: a prospective cohort study.
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DOI：
10.1158/1055-9965.epi-09-0352
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发表时间：
2009-08
期刊：
影响因子：
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通讯作者：
Michaud DS
中科院分区：
文献类型：
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作者：
Bao Y;Giovannucci E;Fuchs CS;Michaud DS
主动吸烟是胰腺癌的既定危险因素，但被动吸烟在胰腺癌发生中的作用仍不清楚。我们的目的是研究环境烟草烟雾是否与胰腺癌风险相关。我们在护士健康研究中前瞻性地检查了86，673名女性。1982年通过问卷调查评估了环境烟草烟雾暴露史。使用考克斯比例风险模型估计相对风险（RR）和95%置信区间（CI）。在24年的随访期间（1982-2006），384名女性被诊断患有胰腺癌。母亲吸烟显著增加胰腺癌的风险（RR，1.42; 95%CI，1.07-1.89），而父亲吸烟与风险无关（RR，0.97; 95%CI，0.77-1.21）。在从不吸烟者中，与母亲吸烟相关的风险仍然升高，尽管不显著（RR，1.52; 95%CI，0.97-2.39）。成人在工作场所或家中被动暴露没有发现相关性。与母亲吸烟的正相关表明，环境烟草烟雾，可能在子宫内或在生命早期，可能与胰腺癌有关。
Active smoking is an established risk factor for pancreatic cancer, but the role of passive smoking in pancreatic carcinogenesis remains unclear. We aimed to examine whether environmental tobacco smoke is associated with pancreatic cancer risk. We prospectively examined 86,673 women in the Nurses' Health Study. History of exposure to environmental tobacco smoke was assessed through questionnaires in 1982. Relative risks (RR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models. During 24 years of follow-up (1982–2006), 384 women were diagnosed with pancreatic cancer. Maternal smoking significantly increased the risk of pancreatic cancer (RR, 1.42; 95% CI, 1.07–1.89), whereas paternal smoking was not related to the risk (RR, 0.97; 95% CI, 0.77–1.21). The risk associated with maternal smoking remained elevated, albeit not significant, among never smokers (RR, 1.52; 95% CI, 0.97–2.39). No association was found for adult passive exposure at work or at home. The positive association with maternal smoking suggests that environmental tobacco smoke, potentially in utero or in early life, may be associated with pancreatic cancer.