Chitosan gel sheet containing drug carriers with controllable drug-release properties
Chitosan gel sheet containing drug carriers with controllable drug-release properties
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DOI：
10.1016/j.colsurfb.2017.12.054
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发表时间：
2018-03-01
影响因子：
5.8
通讯作者：
Murakami, Yoshihiko
中科院分区：
文献类型：
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作者：
Ito, Tomoki;Takami, Taku;Murakami, Yoshihiko
我们制备了“片状水凝胶”(凝胶片)，这是一种由聚乙二醇接枝壳聚糖和可交联性聚合物胶束组成的片状，有望用于伤口愈合。我们优化了聚乙二醇改性工艺，评价了凝胶性能的应变依赖性，得到了柔性凝胶片，并对凝胶片的释药性能进行了评价。最后，我们成功地观察到抗生素四环素(Tet)从只存在于交联剂中的凝胶片中的释放低于从分散在聚合物网络中的凝胶片中的Tet的释放。我们的研究表明，将药物载体引入凝胶片的策略可能有利于构建具有可控药物释放性能的生物材料。(C)2017爱思唯尔B.V.保留所有权利。
We prepared the "sheet-type hydrogel" (gel sheet), a sheet consisting of PEG-grafted chitosan and cross linkable polymeric micelles, that were expected to be used for wound healing. We optimized the PEG-modification process, evaluated the strain-dependence of the gel's properties to obtain flexible gel sheets, and evaluated the drug-release properties of the gel sheets. Finally, we succeeded in observing that the release of the antibiotic tetracycline (TET) from the gel sheet in which TET existed only in the cross-linkers was lower than the release of TET from the sheet in which TET was dispersed in the polymer networks. Our research demonstrates that the strategy of incorporating drug carriers into gel sheets might benefit the construction of biomaterials with controllable drug-release properties. (C) 2017 Elsevier B.V. All rights reserved.