Immunological update on multiple sclerosis
Immunological update on multiple sclerosis
复制标题
DOI：
10.1097/00019052-200106000-00006
复制
发表时间：
2001-06-01
影响因子：
4.8
通讯作者：
Wekerle, H
中科院分区：
文献类型：
--
作者：
Hohlfeld, R;Wekerle, H
目前的回顾最近的文献集中在抗原特异性免疫反应在多发性硬化症。新技术可以精确定量分析多发性硬化症大脑中浸润性T细胞的抗原受体库。新的候选自身抗原，包括b细胞自身抗原，已经被确定，“人源化”的动物模型允许在体内对人类免疫分子进行功能表征。最后，一些治疗试验最近评估了选择性免疫疗法的临床益处。现代医学杂志，14:299-304。(C) 2001 Lippincott Williams & Wilkins。
The present review of the recent literature focuses on antigen-specific immune reactions in multiple sclerosis. New techniques have allowed precise quantitative analysis of the antigen-receptor repertoire of infiltrating T cells in the multiple sclerosis brain. Novel candidate autoantigens, including B-cell autoantigens, have been identified, 'Humanized' animal models allow the functional characterization of human immune molecules in vivo. Finally, several therapeutic trials have recently assessed the clinical benefit of selective immunotherapies. Curr Opin Neurol 14:299-304. (C) 2001 Lippincott Williams & Wilkins.