Treatment of depression in general practice: a controlled trial of flupenthixol (‘Fluanxol’)
Treatment of depression in general practice: a controlled trial of flupenthixol (‘Fluanxol’)
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一般实践中抑郁症的治疗：氟哌噻吨（‘Fluanxol’）的对照试验
DOI：
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
Flemming Frelund
中科院分区：
文献类型：
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作者：
Flemming Frelund
根据抑郁症的任意定义，85名全科医生在一项对照、随机、双盲试验中，在2周内用氟噻吨（“Fluanxof”）d和安慰剂治疗231名患者。男性。女性比例为1：5，平均年龄42岁。症状的严重程度通过评定量表进行评估，令人满意的改善被定义为初始个体评分降低50%或以上。差异具有统计学显著性，X2 = 5.0，d.f.l.，P = 0.025。两组患者在性别、年龄、伴随疾病、其他药物治疗和未服用试验药物方面具有可比性，但无法评估相关的人际关系。患者在治疗的第一周内表现出明显的改善，很少注意到不良反应。结论：在根据试验标准选择的患者中，
SummaryOn the basis of an arbitrary definition of depression, 85 general practitioners treated 231 patients during a 2-week period with flupenthixol (‘Fluanxof)d˚ and placebo in a controlled, randomized, double-blind trial. The male. female ratio was 1:5, and the mean age was 42 years. The severity of the symptoms was assessed by a rating scale, and satisfactory improvement was defined as a reduction of 50% or over of the initial individual scores.Improvement was obtained in 65 % of patients treated with flupenthixol and in 50% of those in the placebo group. The difference is statistically significant, X2 = 5.0, d.f.l.,p = 0.025.The two groups were comparable with respect to sex, age, associated diseases, other medication and failure to take the trial drugs, but relevant personal relationships could not be assessed.Patients showed marked improvement during the first week of treatment and few untoward effects were noted. It is concluded that in patients selected according to the criteria of the trial a bet...