Therapeutic potential of naringin: an overview
Therapeutic potential of naringin: an overview
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DOI：
10.1080/13880209.2016.1216131
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发表时间：
2016-12-01
影响因子：
3.8
通讯作者：
Li, Qi-Yan
中科院分区：
文献类型：
--
作者：
Chen, Rui;Qi, Qiao-Ling;Li, Qi-Yan
研究背景：柚皮苷是一种天然黄酮苷，广泛存在于中草药和柑橘类水果中。研究表明，柚皮苷具有许多生物学和药理学特性，但这些研究的一些评论已经performed.Objective：本综述收集了碎片化的信息，在文献中描述了柚皮苷的提取，其药理学和控制释放制剂。方法：利用Pubmed、Sciencedirect、MEDLINE、Springerlink和Google Scholar等数据库，检索2007- 2015年有关柚皮苷生物学和药理学特性的文献。柚苷调节信号通路并与信号分子相互作用，因此具有广泛的药理活性，包括抗炎、抗癌活性以及对骨再生的作用，代谢综合征、氧化应激、遗传损伤和中枢神经系统（CNS）疾病。收集的信息表明，可以使用几种修改来改进柚皮苷的提取。结论：柚皮苷具有良好的体内研究和临床应用前景。需要对其作用机制进行更详细的研究。
Context: Naringin is a natural flavanone glycoside that is found in the Chinese herbal medicines and citrus fruits. Studies have demonstrated that naringin possesses numerous biological and pharmacological properties, but few reviews of these studies have been performed.Objective: The present review gathers the fragmented information available in the literature describing the extraction of naringin, its pharmacology and its controlled release formulations. Current research progress and the therapeutic potential of naringin are also discussed.Methods: A literature survey for relevant information regarding the biological and pharmacological properties of naringin was conducted using Pubmed, Sciencedirect, MEDLINE, Springerlink and Google Scholar electronic databases from the year 2007-2015.Results: Naringin modulates signalling pathways and interacts with signalling molecules and thus has a wide range of pharmacological activities, including anti-inflammatory, anti-cancer activities, as well as effects on bone regeneration, metabolic syndrome, oxidative stress, genetic damage and central nervous system (CNS) diseases. Information was gathered that showed the extraction of naringin can be improved using several modifications. There has been some progress in the development of controlled release formulations of naringin.Conclusion: Naringin is a promising candidate for further in vivo studies and clinical use. More detailed studies regarding its mechanism of action are required.