Pentraxin 3 in acute respiratory distress syndrome: An early marker of severity
Pentraxin 3 in acute respiratory distress syndrome: An early marker of severity
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DOI：
10.1097/ccm.0b013e3181809aaf
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发表时间：
2008-08-01
影响因子：
8.8
通讯作者：
Pesenti, Antonio
中科院分区：
文献类型：
--
作者：
Mauri, Tommaso;Coppadoro, Andrea;Pesenti, Antonio
目的：正五聚蛋白3（Pentraxin 3）是一种参与天然免疫的液相受体。它属于Pentraxins家族，就像C反应蛋白一样。正五聚蛋白3由多种组织细胞产生，而只有肝脏产生C反应蛋白。正五聚蛋白3在炎症调节中起着独特的作用。急性肺损伤和急性呼吸窘迫综合征的特征是重要的炎症反应。我们研究了五聚环蛋白3作为急性肺损伤和急性呼吸窘迫综合征的严重程度和预后预测指标的作用。设计：我们测量了插管后24小时内（第1天）循环五聚环蛋白3和C反应蛋白水平，24小时后从第一个样品，然后每3天的第一个月，然后每周一次，直到从重症监护室出院。在有临床指征的情况下，也可在支气管肺泡灌洗液中检测正五聚蛋白3。地点：一所大学医学中心的综合重症监护病房。患者：本研究包括21名急性肺损伤和急性呼吸窘迫综合征患者（1994年共识会议标准）。干预措施：无。测量和主要结果：正五聚蛋白3血浆水平较高，在第一天达到峰值（中位数71.05 ng/mL，四分位数范围52.37-117.38 ng/mL，正常值
Objective: Pentraxin 3 is a fluid phase receptor involved in innate immunity. It belongs to the Pentraxins family, as C-reactive protein does. Pentraxin 3 is produced by a variety of tissue cells, whereas only the liver produces C-reactive protein. Pentraxin 3 plays a unique role in the regulation of inflammation. Acute lung injury and acute respiratory distress syndrome are characterized by an important inflammatory reaction. We investigated the role of pentraxin 3 as a marker of severity and outcome predictor of acute lung injury and acute respiratory distress syndrome.Design: We measured circulating pentraxin 3 and C-reactive protein levels within 24 hrs from intubation (day 1), after 24 hrs from the first sample, then every 3 days for the first month and then once a week, until discharge from the intensive care unit. Pentraxin 3 was also measured in bronchoalveolar lavages, performed when clinically indicated.Setting: One university medical center general intensive care unit.Patients: The study included 21 patients affected by acute lung injury and acute respiratory distress syndrome (1994 Consensus Conference criteria).Interventions: None.Measurements and Main Results: Pentraxin 3 plasma levels were high with a peak on the first day (median 71.05 ng/mL, interquartile range 52.37-117.38 ng/mL, normal values