Immunophenotypic differentiation between neoplastic plasma cells in mature B-cell lymphoma vs plasma cell myeloma
Immunophenotypic differentiation between neoplastic plasma cells in mature B-cell lymphoma vs plasma cell myeloma
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DOI：
10.1309/5el22bh45phupm8p
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发表时间：
2007-02-01
影响因子：
3.5
通讯作者：
Karandikar, Nitin J.
中科院分区：
文献类型：
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作者：
Seegmiller, Adam C.;Xu, Yin;Karandikar, Nitin J.
一些非霍奇金淋巴瘤表现出明显的浆细胞分化。在这种情况下，可能很难将这些淋巴瘤与浆细胞瘤或骨髓瘤鉴别，特别是在诊断材料有限的情况下。然而，在这些疾病中，浆细胞中可能存在区分它们的免疫表型差异。本研究描述了41例B系非霍奇金淋巴瘤中肿瘤性浆细胞的免疫表型，并与浆细胞骨髓瘤进行了比较。我们发现淋巴瘤中的浆细胞比骨髓瘤中的浆细胞更可能表达CD19、CD45和表面免疫球蛋白，而不太可能表达CD56。我们进一步表明，CD19和CD56表达可以可靠地用于区分这些实体。骨髓瘤相关性骨病变和骨孤立性浆细胞瘤表现为骨髓瘤样免疫表型。然而，一些髓外浆细胞瘤显示淋巴瘤样表型，这表明，在现实中，他们可能代表非霍奇金淋巴瘤广泛的浆细胞分化。
Some non-Hodgkin lymphomas show marked plasmacytic differentiation. In such cases, it may be difficult to differentiate these lymphomas from plasmacytoma or myeloma, especially with limited diagnostic material. However, there may be immunophenotypic differences in the plasma cells in these disorders that distinguish them. This study characterizes the immunophenotypes of neoplastic plasma cells in 41 cases of B-lineage non-Hodgkin lymphoma and compares them with those in plasma cell myeloma. We found that plasma cells in lymphoma were significantly more likely to express CD19, CD45, and surface immunoglobulin and less likely to express CD56 than those in myeloma. We further show that CD19 and CD56 expression can be used reliably to distinguish these entities. Myeloma-associated osseous lesions and solitary plasmacytoma of bone showed myeloma-like immunophenotypes. However, some extramedullary plasmacytomas showed lymphoma-like phenotypes, suggesting that, in reality, they may represent non-Hodgkin lymphomas with extensive plasmacytic differentiation.