Clear-cell myoepithelial carcinoma of the salivary glands: A clinicopathologic, immunohistochemical, and ultrastructural study of two cases involving the submandibular gland with review of the literature
Clear-cell myoepithelial carcinoma of the salivary glands: A clinicopathologic, immunohistochemical, and ultrastructural study of two cases involving the submandibular gland with review of the literature
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DOI：
10.1016/j.prp.2007.11.006
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发表时间：
2008-01-01
影响因子：
2.8
通讯作者：
Bisceglia, Michele
中科院分区：
文献类型：
--
作者：
Losito, Nunzia Simona;Botti, Gerardo;Bisceglia, Michele
摘要肌上皮癌是一种罕见的涎腺肿瘤，而透明细胞癌的病例更是极为罕见。本文描述了两例MC的CC变异出现在左下颌下腺。这两例病例均涉及老年女性，几乎全部由大的富含糖原的CC组成。这两种情况下，免疫阳性的几个上皮和肌上皮标志物，和电子显微镜（EM）表现出混合上皮和肌样分化。病例1发生于既存多形性腺瘤（“前混合瘤MC”），而病例2为“新发MC”。CC-MC是一种侵袭性肿瘤，经常复发，淋巴结和全身转移。到目前为止，共有14例这种类型的肿瘤报告在唾液腺，两个来自下颌下腺。到目前为止，只有四个案件进行了研究，使用EM。CC-MC的情况下，这里提出的第三和第四个，分别来自下颌下腺，和第一个两例出现在这个位置，其中EM调查成功地证明肌上皮分化。CC-MC需要与不同的原发性和继发性CC肿瘤区分开来。(C)2007年，Elsevier GmbH。All rights reserved.
Myoepithelial carcinoma (MC) is an uncommon neoplasm of the salivary glands, and cases of the clear-cell (CC) variant are extremely rare. Two cases of MC of the CC variant arising in the left submandibular gland are described herein. Both cases, which involved elderly women, almost exclusively consisted of large glycogen-rich CCs. Both cases were immunopositive for several epithelial and myoepithelial markers, and electron microscopy (EM) demonstrated hybrid epithelial and myoid differentiation in both. Case 1 arose in a pre-existing pleomorphic adenoma ("ex mixed tumor MC"), while Case 2 was a "de novo MC". CC-MC is an aggressive tumor with frequent recurrence, lymph node, and systemic metastases. A total of 14 cases of this type of neoplasm have been reported so far in the salivary glands, two arising from the submandibular gland. To date, only four cases have been studied using EM. The cases of CC-MC presented here are the third and fourth ones, respectively, originating from the submandibular glands, and the first two cases arising from this location, in which EM investigation succeeded in demonstrating myoepithelial differentiation. CC-MC needs to be distinguished from diverse primary and secondary CC neoplasms. (C) 2007 Elsevier GmbH. All rights reserved.