Highly regio- and stereoselective synthesis of alkenylboronic esters by copper-catalyzed boron additions to disubstituted alkynes
Highly regio- and stereoselective synthesis of alkenylboronic esters by copper-catalyzed boron additions to disubstituted alkynes
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DOI：
10.1039/c0cc04496b
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Yun, Jaesook
中科院分区：
文献类型：
--
作者：
Kim, Hye Ryung;Yun, Jaesook
在甲醇存在下，铜催化的双（频哪醇合）二硼加成到内部炔上产生具有高水平的区域和立体选择性的烯基硼化合物。通过使用单齿膦配体，特别是P（p-tolyl）（3），提高了催化效率，并且一系列内炔以良好的产率被硼化。
The copper-catalyzed addition of bis(pinacolato) diboron to internal alkynes in the presence of methanol generates alkenylboron compounds with high levels of regio- and stereoselectivities. The catalytic efficiency is increased by using monodentate phosphine ligands, especially P(p-tolyl)(3) and a range of internal alkynes was borylated in good yields.