Anti-Tobacco Mosaic Virus Quassinoids from Ailanthus altissima (Mill.) Swingle
Anti-Tobacco Mosaic Virus Quassinoids from Ailanthus altissima (Mill.) Swingle
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来自臭椿 (Ailanthus altissima (Mill.) Swingle) 的抗烟草花叶病毒苦木素
DOI：
10.1021/acs.jafc.8b01280
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发表时间：
2018-07-18
影响因子：
6.1
通讯作者：
Chen, Qj-Jian
中科院分区：
文献类型：
--
作者：
Tan, Qing-Wei;Ni, Jian-Cheng;Chen, Qj-Jian
苦木素是苦木科特有的苦味成分。从臭椿（Ailanthus altissima（Mill.）Swingle.所有的苦木素类化合物均表现出较强的抗烟草花叶病毒（TMV）活性。初步探讨了苦木素类化合物的结构与抗TMV活性的关系。采用Western blot分析方法，研究了3种苦木素类化合物对烟草花叶病毒（TMV）外壳蛋白（CP）积累的影响。进一步研究了臭椿酮（16）对烟草花叶病毒（TMV）在本氏烟草（Nicotianabenthamiana）中传播的影响。
Quassinoids are bitter constituents characteristic of the family Simaroubaceae. A total of 18 C-20 quassinoids, including nine new quassinoid glycosides, named chuglycosides A-I (1-6 and 8-10), were identified from the samara of Ailanthus altissima (Mill.) Swingle. All of the quassinoids showed potent anti-tobacco mosaic virus (TMV) activity. A preliminary structure-anti-TMV activity relationship of quassinoids was discussed. The effects of three quassinoids, including chaparrinone (12), glaucarubinone (15), and ailanthone (16), on the accumulation of TMV coat protein (CP) were studied by western blot analysis. Ailanthone (16) was further investigated for its influence on TMV spread in the Nicotiana benthamiana plant.