Recent advances in the genetic analysis of PTEN and PI3K innate immune properties
Recent advances in the genetic analysis of PTEN and PI3K innate immune properties
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DOI：
10.1016/j.imbio.2008.07.028
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发表时间：
2008-01-01
期刊：
影响因子：
2.8
通讯作者：
Schabbauer, Gernot
中科院分区：
文献类型：
--
作者：
Guenzl, Philipp;Schabbauer, Gernot
PI 3-激酶途径及其拮抗剂PTEN在调节先天免疫应答中的作用最近才引起科学界的注意。PI 3 K/PTEN信号传导轴因其在导致肿瘤发生的细胞恶性转化中的关键参与而最为著名。PI 3 K在天然免疫调节中的功能，无论是促炎还是抗炎，仍然是一个有争议的问题。毫无疑问，PI 3 K是激活白细胞、启动迁移和促进吞噬作用的重要促炎信号分子。然而，目前尚不清楚PI 3 K和PTEN如何调节免疫应答的幅度。本文综述了近年来利用反向遗传学方法分析PI 3 K/PTEN信号级联在天然免疫中的作用的免疫生物学研究进展。(C)2008年Elsevier GmbH。All rights reserved.
The role of the PI3-kinase pathway and its antagonist PTEN in the regulation of innate immune responses has only recently attracted the attention of the scientific community. The PI3K/PTEN signaling axis is most renowned for its critical involvement in the malignant transformation of cells leading to tumorigenesis. PI3K function in the regulation of innate immunity, either pro-inflammatory or anti-inflammatory, is still a controversial issue. Undoubtedly, PI3K serves as an essential pro-inflammatory signaling molecule to activate leukocytes, initiate migration and facilitate phagocytosis. Nevertheless, it is less clear how PI3K and PTEN modulate the amplitude of immune responses. Here, we review recent advances on the immune biology by means of reverse genetics analyzing the role of the PI3K/PTEN signaling cascade in innate immunity. (C) 2008 Elsevier GmbH. All rights reserved.