Stereospecific synthesis of the α- and β-D-glucopyranosyl ureas
Stereospecific synthesis of the α- and β-D-glucopyranosyl ureas
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DOI：
10.1021/jo0100751
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发表时间：
2001-06-15
影响因子：
3.6
通讯作者：
Isobe, M
中科院分区：
文献类型：
--
作者：
Ichikawa, Y;Nishiyama, T;Isobe, M
一种新的，一锅，两阶段的程序来制备α -和β - d -葡萄糖氨基脲已经开发。利用该方法成功合成了迄今未知的N，N'-二α， α -和α， β - -d -glucopyranosyl脲类化合物。
A new, one-pot, two-stage procedure for the preparation of the alpha- and beta -D-glucopyranosyl ureas has been developed. Oxidation of glucopyranosyl isocyanides provides glucopyranosyl isocyanates, which can be trapped in situ with amines to afford good yields of glucopyranosyl ureas, Application of this method establishes the successful synthesis of the hitherto unknown N,N'-di-alpha,alpha- and alpha,beta -D-glucopyranosyl ureas.