Regional Difference in Seroprevalence of SARS-CoV-2 in Tokyo: Results from the community point-of-care antibody testing
Regional Difference in Seroprevalence of SARS-CoV-2 in Tokyo: Results from the community point-of-care antibody testing
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东京 SARS-CoV-2 血清阳性率的区域差异：社区护理点抗体检测结果
DOI：
10.1101/2020.06.03.20121020
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
E. Kusumi
中科院分区：
文献类型：
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作者：
M. Takita;T. Matsumura;K. Yamamoto;E. Yamashita;K. Hosoda;T. Hamaki;E. Kusumi
由于聚合酶链反应 (PCR) 检测严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 能力的扩展被推迟，血清调查是了解 2019 年冠状病毒病 (COVID-19) 感染人口数量的另一种方法。我们在此报告东京两家社区诊所的 COVID-19 血清阳性率。实施即时免疫诊断测试来检测外周毛细血管血中的 SARS-CoV-2 特异性 IgG 抗体。整个队列 (n = 1,071) 的 SARS-CoV-2 IgG 抗体总体阳性率为 3.83%（95% 置信区间：2.76-5.16）。与东京其他地区相比，东京市中心的 23 个特别区的患病率显着较高（p = 0.02、4.68% [95%CI: 3.08-6.79]，而东京市中心和郊区的患病率分别为 1.83 [0.68-3.95]）。本研究调查的人群的血清流行率对于群体免疫来说较低，这表明需要强有力的疾病控制和预防。对于了解 SARS-COV-2 疫情的概况，基于社区的方法（而不是州或地市级）非常重要。
The serosurvey is an alternative way to know the magnitude of the population infected by coronavirus disease 2019 (COVID-19) since the expansion of capacity of the polymerase chain reaction (PCR) to detect the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was delayed. We herein report seroprevalence of COVID-19 accessed in the two community clinics in Tokyo. The point-of-care immunodiagnostic test was implemented to detect the SARS-CoV-2 specific IgG antibody in the peripheral capillary blood. The overall positive percentage of SARS-CoV-2 IgG antibody is 3.83% (95% confidence interval: 2.76-5.16) for the entire cohort (n =1,071). The central Tokyo of 23 special wards exhibited a significantly higher prevalence compared to the other area of Tokyo (p =0.02, 4.68% [95%CI: 3.08-6.79] versus 1.83 [0.68-3.95] in central and suburban Tokyo, respectively). The seroprevalence of the cohort surveyed in this study is low for herd immunity, which suggests the need for robust disease control and prevention. A community-based approach, rather than state or prefectural levels, is of importance to figure out profiles of the SARS-COV-2 outbreak.