Blockade of the PD-1 pathway enhances the efficacy of adoptive cell therapy against cancer.

Blockade of the PD-1 pathway enhances the efficacy of adoptive cell therapy against cancer.
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DOI:
10.4161/onci.22691
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发表时间:
2013-02-01
期刊:
影响因子:
7.2
通讯作者:
Hwu P
Hwu P
中科院分区:
医学2区
文献类型:
--
作者:
Peng W;Lizée G;Hwu P

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PD-1途径的阻断可以增加位于恶性病灶内或附近的肿瘤特异性T细胞产生的干扰素γ,从而增加免疫效应细胞的趋化因子依赖性运输。这可以提高过继性 T 细胞疗法的功效,以实现卓越的抗肿瘤反应。
The blockade of the PD-1 pathway can increase the production of interferon γ by tumor-specific T cells located within or in the proximity of the malignant lesion, thereby increasing the chemokine-dependent trafficking of immune effector cells. This can boost the efficacy of adoptive T-cell therapy to achieve superior antitumor responses.
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