Effects of lung volume, volume history, and methacholine on lung tissue viscance.
Effects of lung volume, volume history, and methacholine on lung tissue viscance.
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肺容量、容量历史和乙酰甲胆碱对肺组织活力的影响。
DOI：
10.1152/jappl.1989.66.2.977
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
IngramJr,RH
中科院分区：
文献类型：
--
作者：
Kariya,ST;Thompson,LM;Ingenito,EP;IngramJr,RH
我们检查了诱导收缩之前和期间肺容量变化和容量历史对肺阻力（RL）及其组成部分的影响。研究人员对 11 名受试者进行了研究，其中包括 3 名现任哮喘患者和 4 名前哮喘患者。 RL、气道阻力 (Raw) 和组织粘度 (Vtis) 在深吸气前后的不同肺容量下测量，并在乙酰甲胆碱 (MCh) 气雾剂达到最大收缩水平后重复测量。 Vtis 平均为基线 RL 的 9%，MCh 没有改变，深吸气后也没有改变，而是随着肺容量直接增加。 MCh 气溶胶通过增加 Raw 来诱导收缩，而深吸入可逆转这种收缩，与反应性成反比。这样，反应越灵敏的受试者在深呼吸后逆转的程度就越小。反应性与最大收缩程度直接相关，因为反应越灵敏的受试者收缩的程度就越大。这些结果表明，在人类中，Vtis 只占总体 RL 的一小部分，这明显依赖于体积，但不会受到 MCh 诱导的收缩的影响，并且与受试者的反应程度无关。
We examined the effects of lung volume change and volume history on lung resistance (RL) and its components before and during induced constriction. Eleven subjects, including three current and four former asthmatics, were studied. RL, airway resistance (Raw), and, by subtraction, tissue viscance (Vtis) were measured at different lung volumes before and after a deep inhalation and were repeated after methacholine (MCh) aerosols up to maximal levels of constriction. Vtis, which average 9% of RL at base line, was unchanged by MCh and was not changed after deep inhalation but increased directly with lung volume. MCh aerosols induced constriction by increasing Raw, which was reversed by deep inhalation in inverse proportion to responsiveness. such that the more responsive subjects reversed less after a deep breath. Responsiveness correlated directly with the degree of maximal constriction, as more responsive subjects constricted to a greater degree. These results indicate that in humans Vtis comprises a small fraction of overall RL, which is clearly volume-dependent but unchanged by MCh-induced constriction and unrelated to the degree of responsiveness of the subject.