GNPs-CS/KGM as Hemostatic First Aid Wound Dressing with Antibiotic Effect: In Vitro and In Vivo Study
GNPs-CS/KGM as Hemostatic First Aid Wound Dressing with Antibiotic Effect: In Vitro and In Vivo Study
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GNPs-CS/KGM 作为具有抗生素作用的止血急救伤口敷料：体外和体内研究
DOI：
10.1371/journal.pone.0066890
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发表时间：
2013-07-16
期刊：
影响因子：
3.7
通讯作者：
Ren, Bo
中科院分区：
文献类型：
--
作者：
Fan, Li;Cheng, Chong;Ren, Bo
理想的伤口敷料材料应创造良好的愈合环境，具有即时止血效果和抗菌活性。在这项研究中，壳聚糖/葡甘聚糖（CS/KGM）膜包埋庆大霉素负载聚（dex-GMA/AAc）纳米粒子（GNP-CS/KGM膜）作为一种新型的伤口敷料。结果表明，改性后的CS/KGM膜可作为一种有效的创面敷料，具有明显的止血效果。由于其微孔结构，该膜可以有效地从血液中吸收水分并捕获血细胞。载庆大霉素的聚（dex-GMA/AAc）纳米粒（GNP）还具有良好的吸水能力，进一步促进血液凝固。因此，GNP-CS/KGM膜具有伤口愈合和协同作用，有助于停止损伤出血，并且通过向NP中添加庆大霉素还显示出良好的抗菌能力。这些GNPCS/KGM膜可以被认为是有前途的新型生物可降解和生物相容性伤口敷料，具有止血能力和抗生素作用，用于治疗外部出血损伤。
Ideal wound dressing materials should create a good healing environment, with immediate hemostatic effects and antimicrobial activity. In this study, chitosan/konjac glucomannan (CS/KGM) films embedded with gentamicin-loaded poly(dex-GMA/AAc) nanoparticles (giving GNP-CS/KGM films) were prepared as novel wound dressings. The results revealed that the modified CS/KGM films could be used as effective wound dressings and had significant hemostatic effects. With their microporous structure, the films could effectively absorb water from blood and trap blood cells. The gentamicinloaded poly(dex-GMA/AAc) nanoparticles (GNPs) also further promoted blood clotting, with their favorable water uptake capacity. Thus, the GNP-CS/KGM films had wound healing and synergistic effects that helped to stop bleeding from injuries, and also showed good antibiotic abilities by addition of gentamicin to the NPs. These GNPCS/KGM films can be considered as promising novel biodegradable and biocompatible wound dressings with hemostatic capabilities and antibiotic effects for treatment of external bleeding injuries.