ROLE OF HUMAN PLACENTA IN TRANSFER AND METABOLISM OF INSULIN
ROLE OF HUMAN PLACENTA IN TRANSFER AND METABOLISM OF INSULIN
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DOI：
10.1172/jci104464
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发表时间：
1962-01-01
影响因子：
15.9
通讯作者：
ROBERTS, WJ
中科院分区：
文献类型：
--
作者：
BUSE, MG;BUSE, J;ROBERTS, WJ
对28例患者进行了胰岛素-I ~（131）、碘~（131）和~（131）碘标记血清白蛋白跨胎盘中央屏障转运的研究。在分娩前7分钟至4小时向母亲注射或输注示踪量的标记材料。胰岛素-I131和碘化物131的三氯乙酸可溶性分解产物在母体和胎儿之间迅速平衡，而胰岛素-I131给药后，在胎儿血浆中仅发现微量的标记三氯乙酸可沉淀物质。在注射胰岛素-I131后，胎盘捕获了大量标记物质，但在注射碘化物131或放射性碘标记血清白蛋白后未捕获标记物质。当胎盘切片或匀浆在37.5[degree]C下孵育时，注射胰岛素-I131后胎盘中存在的结合标记物质迅速降解。还原型谷胱甘肽的添加到系统中的降解速率增加。足月时胎盘屏障对胰岛素是相对不渗透的。人胎盘在体内捕获并降解大量胰岛素。
The transfer of insulin-I131, iodide131 and radioiodinated serum albumin across the placentral barrier wasstudied in 28 patients. Tracer amounts of labeled material were injected or infused to the mother 7 minutes to 4 hours prior to delivery. The trichloracetic soluble breakdown products of insulin-I131 as well as iodide131 equilibrated rapidly between mother and fetus while only minute amounts of labeled trichloracetic precipitable material were found in fetal plasma after the administration of insulin-I131. Significant amounts of labeled material were trapped by the placenta after the injection of insulin-I131, but not after the injection of iodide131 or radioiodinated serum albumin. The bound labeled material present in the placenta after the injection of Insulin-I131 was rapidly degraded when placental slices or homogenates were incubated at 37.5[degree]C. The addition of reduced glutathione to the system increased the rate of degradation. The placental barrier at term is relatively impermeable to insulin. The human placenta traps and degrades significant amounts of insulin in vivo.