The two-way relationship between nicotine and cortical activity: a systematic review of neurobiological and treatment aspects
The two-way relationship between nicotine and cortical activity: a systematic review of neurobiological and treatment aspects
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DOI：
10.1007/s00406-020-01155-6
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发表时间：
2020-06
影响因子：
4.7
通讯作者：
Carlota de Miquel;B. Pross;I. Papazova;Duygu Güler;A. Hasan
中科院分区：
文献类型：
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作者：
Carlota de Miquel;B. Pross;I. Papazova;Duygu Güler;A. Hasan
尼古丁摄入量和大脑皮层活动密切相关，因为它们可以相互影响。尼古丁与皮层可塑性和兴奋性的诱导和改变有关，而皮层可塑性和兴奋性的变化也可导致个体吸烟行为的改变。本系统综述的目的是，一方面，评估尼古丁能调节对皮层兴奋性和可塑性的影响，另一方面，评估是否修改大脑的兴奋性和可塑性可能会影响一个人的吸烟行为。在PubMed/MEDLINE和PsycINFO数据库中进行了两次系统性文献检索。研究集中于尼古丁能调节对皮层活动的影响或非侵入性脑刺激技术（NIBS）对吸烟行为的治疗效果。全文筛选后，第一次系统检索共纳入22项研究，第二次系统检索共纳入35项研究。尼古丁对皮质活动的影响似乎取决于个人的吸烟状况。虽然剥夺吸烟者似乎普遍受益于尼古丁消费方面的皮质兴奋性和可塑性，相反的是真正的非吸烟者。关于皮质兴奋性的变化如何影响吸烟行为的问题，NIBS是一种潜在的戒烟干预技术。
Nicotine intake and cortical activity are closely related, as they can influence each other. Nicotine is implicated in the induction and modification of cortical plasticity and excitability, whereas a change on cortical plasticity and excitability can also lead to a modification of the smoking behaviour of an individual. The aim of this systematic review was, on the one hand, to evaluate the effects of nicotinergic modulation on cortical excitability and plasticity, and, on the other hand, to assess if modifying the brain’s excitability and plasticity could influence one’s smoking behaviour. Two systematic literature searches in the PubMed/MEDLINE and PsycINFO databases were conducted. Studies focusing either on the impact of nicotinergic modulation on cortical activity or the treatment effect of non-invasive brain stimulation techniques (NIBS) on smoking behaviour were included. A total of 22 studies for the first systematic search and 35 studies for the second one were included after full-text screening. Nicotine’s effect on cortical activity appeared to depend on smoking status of the individual. While deprived smokers seem to generally profit from nicotine consumption in terms of cortical excitability and plasticity, the contrary was true for non-smokers. Regarding the questions of how changes in cortical excitability can influence smoking behaviour, a trend points towards NIBS being a potential intervention technique for smoking cessation.