Is it time to rethink the role of Mg2+ in membrane excitability?
Is it time to rethink the role of Mg2+ in membrane excitability?
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DOI：
10.1097/00001756-200304150-00001
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发表时间：
2003-04
期刊：
影响因子：
1.7
通讯作者：
H. Politi;R. R. Preston-R.
中科院分区：
文献类型：
--
作者：
H. Politi;R. R. Preston-R.
导言在所有具有生物学意义的离子中，镁离子可能是最不受重视的。虽然大多数研究人员都熟悉镁在稳定DNA和细胞膜中的作用，以及作为许多镁依赖酶正常功能所必需的辅因子[1，2]，但他们往往没有考虑到他们是否应该在他们的实验溶液中加入镁，或者实验操作是否会影响有效镁。很少有人认为，细胞内水平可能受到调节，或者它们可能会以与生理相关的方式发生变化。在这篇综述中，我们考察了目前关于镁在可兴奋细胞中的作用的想法，并讨论了关于细胞调节其内部镁水平的最新信息。
INTRODUCTION The magnesium ion is probably the most under-appreciated of all of the biologically significant ions. While most researchers are familiar with the role of Mg in stabilizing DNA and membranes and as a required cofactor for the normal function of many Mg-dependent enzymes [1,2], they often do not give thought to whether they should include Mg in their experimental solutions or whether experimental manipulations may affect available Mg. Few consider the notion that intracellular levels might be regulated or that they could be subject to change in a physiologically relevant manner. In this review, we examine current ideas about the role of Mg in excitable cells and discuss the latest information about the way in which cells regulate their internal Mg levels.