Parkinson's disease impairs the ability to change set quickly
Parkinson's disease impairs the ability to change set quickly
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DOI：
10.1016/s0022-510x(00)00277-x
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发表时间：
2000-04-01
影响因子：
4.4
通讯作者：
Woollacott, MH
中科院分区：
文献类型：
--
作者：
Chong, RKY;Horak, FB;Woollacott, MH
我们测试了帕金森病基底神经节功能障碍损害快速转换能力的假设。通过测量站立受试者腓肠肌或胫骨前肌自动反应的振幅变化来推断改变集合的能力：(1)当表面扰动的方向从向后平移变为脚趾向上旋转时；(2)当受试者被指示在对平移和旋转做出反应时“给予”或“抵抗”时。在实验1中，通过在一系列向后平移后抑制腓肠肌对脚趾向上旋转的反应来评估感觉运动集的变化。与健康的年轻和老年受试者不同，帕金森受试者不会立即改变第一次旋转的感觉运动设置，但需要几次旋转才能改变他们的反应。当被要求在向后平移和脚趾向上旋转之间交替做出反应时，帕金森患者腓肠肌反应的幅度变化较小。在一项实验2中，帕金森患者在使用认知集来调整他们的反应方面没有任何困难，尤其是在被指示“抵制”干扰时。一小部分健康的老年受试者也有快速换组的困难，但比帕金森患者的程度要小。左旋多巴药物并没有提高帕金森患者快速改变设定的能力。这些结果表明，在帕金森病中受到影响的基底神经节是能够快速改变设置的关键神经基质。(C) 2000 Elsevier Science B.V.版权所有
We tested the hypothesis that basal ganglia dysfunction in Parkinson's disease impairs the ability to quickly change set. The ability to change set was inferred by measuring the change in the amplitude of automatic gastrocnemius or tibialis anterior muscle responses in standing subjects: (1) when the direction of a surface perturbation changed from a backward translation to a toes up rotation; and (2) when subjects were instructed to 'give' or 'resist' while responding to the translations and rotations. In experiment 1, a change in sensorimotor set was assessed by the suppression of gastrocnemius responses to toes up rotations following a series of backward translations. Unlike healthy young and older subjects, Parkinson subjects did not change sensorimotor set immediately to the first rotation, but needed several rotations to change their responses. When required to alternate their responses between backward translations and toes up rotations, Parkinson subjects showed a smaller amplitude change in gastrocnemius responses. An experiment 2, Parkinson subjects had mon difficulty in using cognitive set to modify their responses, especially when instructed to 'resist' the perturbations. A small number of healthy older subjects also had difficulties changing set quickly, but to a lesser extent than the Parkinson subjects. Levodopa medication did not improve the Parkinson subjects' ability to change set quickly. These results suggest that the basal ganglia, which are affected in Parkinson's disease, are critical neural substrates in the ability to change set quickly. (C) 2000 Elsevier Science B.V. All rights reserved.