Prevalence of symptoms related to interstitial cystitis in women: A population based study in Finland
Prevalence of symptoms related to interstitial cystitis in women: A population based study in Finland
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DOI：
10.1016/s0022-5347(05)64847-1
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发表时间：
2002-07-01
影响因子：
6.6
通讯作者：
Auvinen, A
中科院分区：
文献类型：
--
作者：
Leppilahti, M;Tammela, TLJ;Auvinen, A
目的：间质性膀胱炎是一种慢性炎症性膀胱病。尽管进行了深入的研究，但其患病率、病因、诊断和适当的治疗仍然难以捉摸。我们估计了芬兰女性间质性膀胱炎相关泌尿症状的患病率。材料和方法：我们从芬兰人口登记中随机选择了2,000名年龄在18岁到71岁之间的研究参与者。通过邮寄给受试者的有效的O‘Leary-Sant间质性膀胱炎症状和问题指数问卷来评估尿路症状的患病率。症状和问题评分高(12分或更高)的女性，包括夜尿2分或以上，疼痛2分或更多，不包括尿路感染和怀孕，被认为最有可能患有间质性膀胱炎。结果：2次投递后的应答率为67.2%(1343名受访者)。在进一步排除后，1331名女性(66.6%)组成了最终的研究小组。在1,331名受访者中，11名(0.8%)报告了严重的症状和问题(12岁或以上)，其中6名(0.45%)符合可能的间质性膀胱炎的标准。结论：与可能的间质性膀胱炎相对应的尿路症状的患病率为450/100.000(95%可信区间100~800)，比以前报道的高出一个数量级。
Purpose: Interstitial cystitis is a chronic inflammatory bladder disease. Despite intensive research its prevalence, etiology, diagnosis and appropriate treatment remain elusive. We estimated the prevalence of urinary symptoms related to interstitial cystitis in women in Finland.Materials and Methods: We randomly selected 2,000 study participants 18 to 71 years old from the Finnish population register. The prevalence of urinary symptoms was evaluated using the validated O'Leary-Sant interstitial cystitis symptom and problem index questionnaire, which was mailed to subjects. Women with high (12 or greater) symptom and problem scores, including nocturia 2 or greater, pain 2 or greater, and excluding urinary infection and pregnancy, were considered most likely to have interstitial cystitis.Results: The response rate after 2 mailings was 67.2% (1,343 respondents). After further exclusions 1,331 women (66.6%) comprised the final study group. Of these 1,331 respondents 11 (0.8%) reported severe symptoms and problems (12 or greater), including 6 (0.45%) who fulfilled the criteria for probable interstitial cystitis.Conclusions: The prevalence of urinary symptoms corresponding to probable interstitial cystitis is 450/100.000 (95% confidence interval 100 to 800), which is an order of magnitude higher than previously reported.