Antidepressant-like effects of p-synephrine in mouse models of immobility tests
Antidepressant-like effects of p-synephrine in mouse models of immobility tests
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DOI：
10.1016/0304-3940(96)12895-0
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发表时间：
1996-08-23
影响因子：
2.5
通讯作者：
Kim, YH
中科院分区：
文献类型：
--
作者：
Song, DK;Suh, HW;Kim, YH
我们研究了对辛弗林对小鼠不动行为和自发运动活动的影响。口服 1 至 10 mg/kg 剂量的对辛弗林可显着缩短小鼠悬尾试验和强迫游泳试验中不动的持续时间。在 30 mg/kg 剂量下，两项测试中的不动持续时间均恢复至对照值。皮下注射哌唑嗪盐酸盐（62.5μg/kg），一种α（1）肾上腺素受体拮抗剂，可阻断对辛弗林（3mg/kg）引起的悬尾试验中不动性的降低。口服剂量从 0.3 至 10 mg/kg 的对辛弗林不会改变自发运动活动。这些结果表明，p-辛弗林通过刺激 α(1) 肾上腺素受体，在不动测试小鼠模型中引发抗抑郁样活性。
We studied the effects of p-synephrine on the immobility behaviors and on the spontaneous motor activity in mice. p-Synephrine at oral doses from 1 to 10 mg/kg significantly decreased the duration of immobility in the tail suspension test and the forced swimming test in mice. At 30 mg/kg, the duration of immobility was returned to control values in both tests. Subcutaneous administration of prazosin hydrochloride (62.5 mu g/kg), an alpha(1) adrenoceptor antagonist, blocked the p-synephrlne (3 mg/kg)-induced decrease in immobility in the tail suspension test. p-Synephrine did not change the spontaneous motor activity at oral doses from 0.3 to 10 mg/kg. These results suggest that p-synephrine elicits an antidepressant-like activity in mouse models of immobility tests, through the stimulation of alpha(1) adrenoceptors.