WHITE-MATTER LESIONS IN MR IMAGING OF CLINICALLY HEALTHY BRAINS OF ELDERLY SUBJECTS - POSSIBLE PATHOLOGICAL BASIS
WHITE-MATTER LESIONS IN MR IMAGING OF CLINICALLY HEALTHY BRAINS OF ELDERLY SUBJECTS - POSSIBLE PATHOLOGICAL BASIS
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DOI：
10.1148/radiology.162.2.3797666
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发表时间：
1987-02-01
期刊：
影响因子：
19.7
通讯作者：
HAYMAN, LA
中科院分区：
文献类型：
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作者：
KIRKPATRICK, JB;HAYMAN, LA
在对 20%-30% 神经健康的老年受试者进行的脑部磁共振 (MR) 成像研究中，出现斑片状白质病变。为了确定这些受试者在尸检时出现组织学上可验证的白质病变的频率，作者对 15 名年龄在 52-72 岁的临床健康受试者的连续显微镜全脑切片进行了检查。在 12 例中发现了小的白质病变。在这 12 例中，8 个大脑中存在萎缩性血管周围脱髓鞘区域。这些不是常见的可产生急性坏死的血栓、栓塞或缺血性血管病变。这种轻微的血管功能不全会产生萎缩，这已在病理学文献中得到认可，但其临床意义仍不清楚。其他可见的病变包括四个大脑卵圆中心的小血管畸形，三个大脑的侧脑室憩室延伸到白质，以及一个孤立的中央白质梗死。所有这些病变可能都是在神经健康老年人群的磁共振成像研究中看到的斑片状白质斑的基础。
Patchy white-matter lesions occur in the magnetic resonance (MR) imaging brain studies of 20%-30% of neurologically healthy elderly subjects. To determine the frequency of histologically verifiable white-matter lesions at autopsy in such subjects the authors examined serial, microscopic, whole brain sections from 15 clinically healthy subjects aged 52-72 years. Small white-matter lesions were found in 12. In these 12, zones of atrophic perivascular demyelination were present in eight brains. These are not the familiar thrombotic, embolic, or ischemic vascular lesions that produce acute necrosis. This mild vascular insufficiency produces atrophy, which has been recognized in the pathology literature but whose clinical significance remains unknown. Other lesions seen were small vascular malformations in the centrum ovale in four brains, diverticula of the lateral ventricle extending into the white matter in three, and an isolated central white-matter infarction in one. All of these lesions are probably the basis of the patchy white-matter lesins seen on MR imaging studies in the neurologically healthy elderly population.