Value and Validity of Coronavirus Antibody Testing.
Value and Validity of Coronavirus Antibody Testing.
复制标题
冠状病毒抗体检测的价值和有效性。
DOI：
10.36076/ppj.2020/23/s381
复制
发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
L. Manchikanti
中科院分区：
文献类型：
--
作者：
A. Mahajan;L. Manchikanti
背景
介入性疼痛管理界见证了COVID-19大流行在美国各地大量减少了择期介入手术和新患者就诊，直到美国重新开放，重新开始介入手术和择期外科手术。卫生保健提供者，沿着基本工作人员和病人，继续关注以安全和负责任的方式运作。因此，通过长期接触新患者和在高风险环境中接受干预的患者的测试卫生保健工作者创造了一定程度的舒适度。由于美国和世界遭受持续的信息流行病，有大量的错误信息，以及一些关于分子，抗原和抗体检测的适当信息。因此，本文旨在描述冠状病毒抗体检测的价值和有效性。
方法
文献综述。
结果
抗体测试检测抗体或免疫球蛋白，作为对SARS-CoV-2感染的人体免疫反应产生。阳性结果表明该个体可能已暴露于SARS-CoV-2。当免疫球蛋白M（IgM）抗体存在时，它们可以指示活动性或近期感染，而免疫球蛋白G（IgG）抗体在感染过程中出现较晚，通常可以指示过去的感染，但不排除最近感染的患者仍然具有传染性，特别是当IgM抗体也同时检测时。虽然过去的知识表明，对于病毒感染，IgG抗体通常比IgM抗体持续时间更长，并提供对再次感染的免疫力，但尚不清楚COVID-19是否如此。
限制
缺乏文献的叙述性评论。
结论
抗体测试已开发用于仅检测IgG，IgG和IgM两者，或总抗体。目前，多种抗体测试可在美国使用。在对截至4月底的54项可用研究（主要来自中国）的回顾中，症状发作后15至21天IgG/IgM联合检测的汇总结果准确度为91.4%（95%CI，87.0 - 96.6）。因此，抗体检测在持续的Covid-19大流行中提供了希望和危险。
BACKGROUND
The interventional pain management community saw the COVID-19 pandemic decimate elective interventional procedures and new patient visits across the United States until the reopening of America and the restarting of interventional procedures and elective surgical procedures began again. Health care providers, along with essential workers and patients, continue to be concerned about functioning in a safe and responsible manner. Consequently, a level of comfort is created by the testing health care workers with long exposure to new patients and patients undergoing interventions in high risk environments. As the United States and the world suffers from an ongoing infodemic, there are substantial amounts of misinformation, and some appropriate information being produced on molecular, antigen and antibody testing. Consequently, this manuscript is undertaken to describe the value and validity of coronavirus antibody testing.
METHODS
Literature review.
RESULTS
Antibody tests detect antibodies or immunoglobulins that are produced as the human immune response to SARS-CoV-2 infection. A positive result suggests that the individual has potentially been exposed to SARS-CoV-2. When immunoglobulins M (IgM) antibodies are present, they can indicate an active or recent infection, whereas immunoglobulin G (IgG) antibodies show up later in the infection process and can often indicate a past infection, but does not exclude recently infected patients who can still be contagious, especially when IgM antibodies are also concurrently detected. While past knowledge indicates that for viral infections, IgG antibodies usually persist longer than IgM antibodies and provide immunity from re-infection, it is not clearly known if that is true for COVID-19.
LIMITATIONS
A narrative review with paucity of literature.
CONCLUSION
Antibody tests have been developed to detect IgG only, both IgG and IgM, or total antibodies. At present, multiple antibody tests are available for use in the United States. In a review of 54 available studies through the end of April, mostly from China, the accuracy of pooled results for combination IgG/IgM tests was 91.4% (95% CI, 87.0 - 96.6) for 15 to 21 days post-symptom onset. Thus, antibody tests provide a promise and a peril in the ongoing Covid-19 pandemic.
循证医学：不确定性的科学和概率的艺术。
DOI：
10.1001/virtualmentor.2013.15.1.fred1-1301
发表时间：
2013
期刊：
The virtual mentor : VM
影响因子：
--
作者：
Rysavy,Matthew
通讯作者：
Rysavy,Matthew