Identification and geographic distribution of the ACE-1R mutation in the malaria vector Anopheles gambiae in south-western Burkina Faso, West Africa
Identification and geographic distribution of the ACE-1R mutation in the malaria vector Anopheles gambiae in south-western Burkina Faso, West Africa
复制标题
DOI：
10.4269/ajtmh.2008.78.298
复制
发表时间：
2008-02-01
影响因子：
3.3
通讯作者：
Chandre, Fabrice
中科院分区：
文献类型：
--
作者：
Djogbenou, Luc;Dabire, Roch;Chandre, Fabrice
冈比亚按蚊对有机磷和氨基甲酸酯杀虫剂的抗药性首次在西非科特迪瓦报道。随后的研究表明，它是由乙酰胆碱酯酶的氧阴离子孔中的单点突变（ace-1（R）突变）引起的。我们调查了ace-1（R）突变在AN中的分布和患病率。冈比亚有限公司布基纳法索西南部七个地点的人口。ace-1（R）突变存在于M型和S型两种分子形式的An中。gambiae s.s.，但它在《安》中没有出现。阿拉伯的。S型的频率为0.25 ~ 0.5，M型的频率为0.04 ~ 0.13，但它们同域分布。纯合抗性的缺乏表明与突变相关的强烈遗传成本。这些数据表明，有机磷和氨基甲酸酯的耐药性所赋予的目标网站不敏感性正在蔓延的人口。冈比亚公司来自西非。
Resistance of Anopheles gambiae to organophosphate and carbamate insecticides was first reported in Cote d'Ivoire, West Africa. Subsequent studies revealed that it resulted from a single point mutation in the oxyanion hole of the acetycholinesterase enzyme (ace-1(R) mutation). We investigated the distribution and prevalence of the ace-1(R) mutation in An. gambiae s.l. populations from seven locations in south-western Burkina Faso. The ace-1(R) mutation was found in both M and S molecular forms of An. gambiae s.s., but it was absent in An. arabiensis. Its frequency ranged from 0.25 to 0.5 in S form and 0.04 to 0.13 in M form, though they were sympatric. The lack of homozygous resistance indicated a strong genetic cost associated with the mutation. These data suggest that organophosphate and carbamate resistance conferred by target site insensitivity is spreading in populations of An. gambiae s.s. from West Africa.