TIMP3 and CCNA1 hypermethylation in HNSCC is associated with an increased incidence of second primary tumors.
TIMP3 and CCNA1 hypermethylation in HNSCC is associated with an increased incidence of second primary tumors.
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DOI：
10.1186/1479-5876-11-316
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发表时间：
2013-12-20
影响因子：
7.4
通讯作者：
Vettore AL
中科院分区：
文献类型：
--
作者：
Rettori MM;de Carvalho AC;Longo AL;de Oliveira CZ;Kowalski LP;Carvalho AL;Vettore AL
启动子区域的超甲基化与基因表达的抑制相关，并且已被认为是几种肿瘤类型的潜在分子标志物，包括头颈部鳞状细胞癌（HNSCC）。为了评估基因高甲基化谱作为预后标志物的价值，本回顾性研究采用QMSP方法测定了70例HNSCC患者19个基因的甲基化状态。原发性HNSCC甲基化分析显示CCNA 1、DAPK、MGMT、TIMP 3和SFRP 1基因高甲基化，具有较高的特异性和敏感性。TIMP 3和CCNA 1高甲基化与较低的第二原发无瘤生存率显著相关（分别为p = 0.007和p = 0.001;对数秩检验）。这项研究首次提出了CCNA 1和TIMP 3高甲基化作为识别HNSCC受试者发生第二原发癌风险的有用工具。
Hypermethylation in the promoter regions is associated with the suppression of gene expression and has been considered a potential molecular marker for several tumor types, including head and neck squamous cell carcinomas (HNSCC). To evaluate the gene hypermethylation profile as a prognostic marker, this retrospective study used a QMSP approach to determine the methylation status of 19 genes in 70 HNSCC patients. The methylation profile analysis of primary HNSCC revealed that genes CCNA1, DAPK, MGMT, TIMP3 and SFRP1 were frequently hypermethylated, with high specificity and sensitivity. TIMP3 and CCNA1 hypermethylation was significantly associated with lower rates of second primary tumor-free survival (p = 0.007 and p = 0.001; log-rank test, respectively). This study, for the first time, presents CCNA1 and TIMP3 hypermethylation as a helpful tool to identify HNSCC subjects at risk of developing second primary carcinomas.
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DOI：
10.1158/1055-9965.epi-08-0192
发表时间：
2008-10
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Brait M;Begum S;Carvalho AL;Dasgupta S;Vettore AL;Czerniak B;Caballero OL;Westra WH;Sidransky D;Hoque MO
通讯作者：
Hoque MO
影响因子：
6.4
作者：
de Carvalho, Fabricio;Colleoni, Gisele W. B.;Vettore, Andre L.
通讯作者：
Vettore, Andre L.
DOI：
10.1016/0360-3016(92)91022-f
发表时间：
1992-01-01
影响因子：
7
作者：
FIJUTH, J;MAZERON, JJ;LEBOURGEOIS, JP
通讯作者：
LEBOURGEOIS, JP
影响因子：
2.5
作者：
KOWALSKI, LP;BATISTA, MBP;TRIPPE, N
通讯作者：
TRIPPE, N
影响因子：
8
作者：
Brabender, J;Usadel, H;Danenberg, PV
通讯作者：
Danenberg, PV