Association between T lymphocyte sub-sets apoptosis and peripheral blood mononuclear cells oxidative stress in systemic lupus erythematosus
Association between T lymphocyte sub-sets apoptosis and peripheral blood mononuclear cells oxidative stress in systemic lupus erythematosus
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DOI：
10.3109/10715762.2011.555765
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发表时间：
2011-05-01
影响因子：
3.3
通讯作者：
Wanchu, Ajay
中科院分区：
文献类型：
--
作者：
Shah, Dilip;Aggarwal, Ashish;Wanchu, Ajay
氧化应激增加和淋巴细胞凋亡是自身免疫性疾病系统性红斑狼疮(SLE)的标志。然而，系统性红斑狼疮患者氧化应激与T淋巴细胞凋亡之间的关系尚不清楚。为探讨氧化应激与T淋巴细胞凋亡之间的相互作用与病情严重程度的关系，对氧化应激谱和T淋巴细胞凋亡进行了研究。ROS、MDA和CD_4水平升高
Increased oxidative stress and lymphocyte apoptosis are a hallmark of the autoimmune disease systemic lupus erythematosus (SLE). However, the association between oxidative stress and T lymphocytes apoptosis has still to be elucidated in SLE. In order to appraise the interaction between oxidative stress and T lymphocyte apoptosis with the severity of disease, oxidative stress profile and T lymphocytes apoptosis were studied. Increased levels of ROS, MDA and CD4