Whole‐body vibration for patients with nonalcoholic fatty liver disease: a 6‐month prospective study
Whole‐body vibration for patients with nonalcoholic fatty liver disease: a 6‐month prospective study
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非酒精性脂肪肝患者的全身振动：一项为期 6 个月的前瞻性研究
DOI：
10.14814/phy2.14062
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发表时间：
2019
影响因子：
2.5
通讯作者：
J. Shoda
中科院分区：
文献类型：
--
作者：
Sechang Oh;N. Oshida;Noriko Someya;Tsuyoshi Maruyama;T. Isobe;Y. Okamoto;Taeho Kim;Bokun Kim;J. Shoda
体育锻炼已被证明对管理非酒精性脂肪性肝病（NAFLD）有好处。然而，在日常生活中，在没有帮助的情况下保持锻炼可能是困难的。最近引入了全身振动装置（WBV）作为一种运动方式，可能适用于运动困难的患者。我们在NAFLD患者中测试了WBV并评估了其有效性。我们在25例NAFLD患者中研究了6个月WBV计划对肝脏脂肪变性及其基础病理生理学的影响。17例NAFLD患者被指定为对照组。WBV运动后，研究组体重仅比对照组下降2.5%。然而，我们发现肌肉面积（+2.6%）和力量（+20.5%）显着增加，脂肪量减少（-6.8%）。肝脏（-9.9%）和内脏（-6.2%）脂肪含量也显著降低（P < 0.05）。肝硬度显著降低（−15.7%），沿着炎症标志物水平改善;肿瘤坏死因子α（−50.9%）、脂联素（+12.0%）、铁蛋白（−33.2%）和高敏C反应蛋白（−43.0%）（P < 0.05）。这些结果表明，WBV是NAFLD患者的一种有效，高效和方便的运动选择。
Physical exercise has demonstrated benefits for managing nonalcoholic fatty liver disease (NAFLD). However, in daily life maintaining exercise without help may be difficult. A whole‐body vibration device (WBV) has been recently introduced as an exercise modality that may be suitable for patients who have difficulty engaging in exercise. We tested WBV in patients with NAFLD and estimated its effectiveness. We studied the effects of a 6‐month WBV program on hepatic steatosis and its underlying pathophysiology in 25 patients with NAFLD. Seventeen patients with NAFLD were designated as a control group. After WBV exercise, body weight in the study group decreased by only 2.5% compared with the control group. However, we found significant increases in muscle area (+2.6%) and strength (+20.5%) and decreases in fat mass (−6.8%). The hepatic (−9.9%) and visceral (−6.2%) fat content also significantly decreased (P < 0.05). There was substantial lowering of hepatic stiffness (−15.7%), along with improvements in the levels of inflammatory markers; tumor necrosis factor alpha (−50.9%), adiponectin (+12.0%), ferritin (−33.2%), and high‐sensitivity C‐reactive protein (−43.0%) (P < 0.05). These results suggest that WBV is an exercise option for patients with NAFLD that is effective, efficient, and convenient.
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影响因子：
6
作者：
Ding, XK;Saxena, NK;Anania, FA
通讯作者：
Anania, FA
影响因子：
29.4
作者：
Fabbrini, Elisa;Mohammed, B. Selma;Klein, Samuel
通讯作者：
Klein, Samuel
DOI：
10.1210/jcem.86.12.8075
发表时间：
2001-12
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Bret H. Goodpaster;Jing He;Simon C. Watkins;David E. Kelley
通讯作者：
Bret H. Goodpaster;Jing He;Simon C. Watkins;David E. Kelley
影响因子：
7.7
作者：
Krssak, M;Brehm, A;Roden, M
通讯作者：
Roden, M
影响因子：
15.9
作者：
Kim, Ja-Young;De Wall, Esther Van;Scherer, Philipp E.
通讯作者：
Scherer, Philipp E.