Activation of phagocytes by Helicobacter pylori correlates with the clinical presentation of the gastric infection.
Activation of phagocytes by Helicobacter pylori correlates with the clinical presentation of the gastric infection.
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幽门螺杆菌对吞噬细胞的激活与胃感染的临床表现相关。
DOI：
10.3109/00365549509032729
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发表时间：
1995
影响因子：
--
通讯作者：
L. Andersen
中科院分区：
文献类型：
--
作者：
H. Nielsen;L. Andersen
只有少数幽门螺杆菌感染的受试者发展为临床胃十二指肠疾病。目前尚不清楚宿主因素或细菌毒力特性是否与致病机制有关。我们之前已经证明了25-35-kDa蛋白在细菌声索中具有吞噬细胞刺激活性。用健康供体细胞与n -f-蛋氨酸-亮氨酸-苯丙氨酸和C5a过敏毒素比较，对15 H.中性粒细胞和单核细胞的趋化性和化学发光性进行了评估。细菌蛋白(s)诱导单核细胞化学发光的效力在溃疡患者（1 +/- 1 μ g /ml诱导>或对照反应增加2倍）和慢性活动性胃炎（1 +/- 1 μ g /ml）中明显高于浅表性胃炎（> 1000 μ g /ml, p<0.05）。中性粒细胞的激活在十二指肠溃疡菌株中也明显更有效。各组细菌制剂的趋化活性无显著差异。我们得出结论，吞噬细胞明显活化的菌株与临床溃疡疾病的存在有关，支持溃疡源性菌株的存在。
Only a minority of subjects with Helicobacter pylori infection develop clinical gastroduodenal disease. It is unclear whether host factors or bacterial virulence properties contribute to the pathogenic mechanisms. We have previously demonstrated a 25-35-kDa protein with phagocyte stimulatory activity in bacterial sonicates. Protein preparations were made from 15 H. neutrophil and monocyte chemotaxis and chemiluminescence was assessed with cells from healthy donors in comparison with N-f-methionyl-leucyl-phenylalanine and C5a anaphylatoxin. The potency of bacterial protein(s) for induction of monocyte chemiluminescence was significantly higher for strains from ulcer patients (1 +/- 1 microgram/ml induced > or = twofold increase of control response) and chronic active gastritis (1 +/- 1 microgram/ml) compared with superficial gastritis (> 1,000 microgram/ml, p<0.05). Neutrophil activation was also significantly more potent with strains from duodenal ulcer disease. The chemotactic activity of bacterial preparations was not significantly different between the groups. We conclude that bacterial strains with pronounced activation of phagocytes are associated with the presence of clinical ulcer disease, supporting the existence of ulcerogenic strains.
影响因子：
29.4
作者：
YOSHIDA, N;GRANGER, DN;KVIETYS, PR
通讯作者：
KVIETYS, PR
幽门螺杆菌诱导的大鼠微血管蛋白渗漏：中性粒细胞、肥大细胞和血小板的作用。
影响因子：
29.4
作者：
Kurose,I;Granger,DN;EvansJr,DJ;Evans,DG;Graham,DY;Miyasaka,M;Anderson,DC;Wolf,RE;Cepinskas,G;Kvietys,PR
通讯作者：
Kvietys,PR