Evidence for an involvement of the brain cholecystokinin B receptor in anxiety.
Evidence for an involvement of the brain cholecystokinin B receptor in anxiety.
复制标题
大脑胆囊收缩素 B 受体参与焦虑的证据。
DOI：
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发表时间：
1991
影响因子：
11.1
通讯作者：
G. Woodruff
中科院分区：
文献类型：
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作者：
L. Singh;A. S. Lewis;M. J. Field;J. Hughes;G. Woodruff
在大鼠高架X-迷宫焦虑模型中，研究了神经肽胆囊收缩素（CCK）受体激动剂和拮抗剂的作用。选择性CCK-B受体拮抗剂CI-988（PD 134308）和L-365，260产生抗焦虑样作用，而CCK-A受体拮抗剂MK-329的效力分别为313和200倍。脑室内注射非选择性CCK受体激动剂雨蛙肽或选择性CCK-B受体激动剂五肽胃泌素可剂量依赖性地增加焦虑水平。CI-988剂量依赖性地拮抗对五肽胃泌素的焦虑反应，但不拮抗戊四氮诱导的焦虑反应。这些结果强烈表明，激活大脑CCK-B受体诱导焦虑和选择性拮抗剂，这种受体代表一个单独的类抗焦虑剂。
The effect of neuropeptide cholecystokinin (CCK) receptor agonists and antagonists was examined in the rat elevated X-maze model of anxiety. The selective CCK-B receptor antagonists CI-988 (PD 134308) and L-365,260 produced anxiolytic-like effects, whereas MK-329, a CCK-A receptor antagonist, was respectively less potent by factors of 313 and 200. The intracerebroventricular administration of the nonselective CCK receptor agonist caerulein or the selective CCK-B receptor agonist pentagastrin increased dose dependently the level of anxiety. CI-988 dose dependently antagonized the anxiogenic response to pentagastrin but not that induced by pentylenetetrazol. These results strongly suggest that activation of the brain CCK-B receptor induces anxiety and that selective antagonists of this receptor represent a separate class of anxiolytic agents.