Trends in the prevalence of dementia in Japan.
Trends in the prevalence of dementia in Japan.
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DOI：
10.1155/2012/956354
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发表时间：
2012
影响因子：
--
通讯作者：
Kaye JA
中科院分区：
文献类型：
--
作者：
Dodge HH;Buracchio TJ;Fisher GG;Kiyohara Y;Meguro K;Tanizaki Y;Kaye JA
在日本，关于痴呆症的趋势及其亚型患病率的数据很少。本文的目的是：（1）总结日本痴呆症的流行病学研究，包括研究方案和诊断标准的相关细节，（2）比较研究中全因痴呆症的年龄特异性患病率，（3）评估阿尔茨海默病（AD）与血管性痴呆（VaD）随时间的趋势。我们回顾了诊断标准，全因痴呆症的患病率，和AD/VaD的比例，从8个大的人口研究痴呆症在日本。与冲绳1992年的研究相比，1994年、1998年、2005年和2008年进行的研究在控制了年龄和性别后，使用泊松回归模型显示全因痴呆的患病率更高。与美国和一些欧洲国家相比，日本的全因痴呆症患病率正在增加。与VaD相比，AD的患病率似乎随着时间的推移而增加，但诊断标准的巨大差异，可能的区域差异以及男性和女性之间痴呆亚型患病率的差异使得很难在国家一级得出关于这一趋势的结论。进一步的研究，例如，将血管疾病的人群归因风险与痴呆症的患病率和发病率进行比较，可能有助于澄清病因亚型的区域差异。
There is a paucity of data regarding trends in dementia and its subtype prevalence in Japan. Our aims in the current paper are to: (1) summarize epidemiological studies of dementia in Japan including relevant details of study protocol and diagnostic criteria, (2) compare the age-specific prevalence of all-cause dementia among studies, and (3) assess the trends in Alzheimer's disease (AD) versus vascular dementia (VaD) over time. We reviewed diagnostic criteria, all-cause dementia prevalence, and the AD/VaD ratio from 8 large population studies of dementia in Japan. Compared with the Okinawa 1992 study, studies conducted in 1994, 1998, 2005, and 2008 had a higher prevalence of all-cause dementia using Poisson regression models, after controlling for age and sex. In contrast to the US and some European countries, all-cause dementia prevalence is increasing in Japan. The prevalence of AD as opposed to VaD seems to be increasing over time, but large variability in diagnostic criteria, possible regional variability, and differences in prevalence of subtypes of dementia between men and women make it difficult to draw a conclusion about this trend at the national level. Further studies, for example, comparing the population attributable risk of vascular diseases to the prevalence and incidence of dementia could help to clarify the regional variations in etiological subtypes.