The monoamine oxidase A gene may influence the means used in suicide attempts
The monoamine oxidase A gene may influence the means used in suicide attempts
复制标题
DOI：
10.1097/00041444-200509000-00009
复制
发表时间：
2005-09-01
影响因子：
0.9
通讯作者：
Malafosse, A
中科院分区：
文献类型：
--
作者：
Courtet, P;Jollant, F;Malafosse, A
目的令人信服的证据表明5-羟色胺系统功能障碍与某些行为障碍有关，包括自杀行为和冲动攻击。最近发现了单胺氧化酶A基因启动子区域的一个功能性多态，2-3个等位基因的存在与高转录水平、中枢神经系统5-羟色胺能反应性和冲动性攻击有关。该基因内含子2(单胺氧化酶A-CaN)中的二核苷酸重复序列已被描述，并与可变数目的Tandom Repeats(VNTR)连锁不平衡。本研究的目的是在大样本中调查单胺氧化酶A基因是否与自杀行为的易感性有关。方法我们对738名有过自杀企图的西欧高加索人和222名没有自杀行为史的相同种族的对照进行了基因分型。结果未发现这两个单胺氧化酶A基因变异与自杀行为有任何关联。然而，在使用暴力手段自杀未遂的男性中，uVNTR2-3等位基因的频率显著高于使用非暴力手段自杀的男性。UVNTR2-3等位基因与uVNTR1-4等位基因的优势比为2.17[95%可信区间(1.08-4.35)]。结论这些结果提示高活性单胺氧化酶A基因启动子等位基因的过量可能与自杀行为倾向于暴力行为的特征有关。
ObjectiveCompelling evidence suggests that serotonin system dysfunction is associated with certain behavioral disorders, including suicidal behavior and impulsive aggression. A functional polymorphism in the promoter region of the monoamine oxidase A gene (uVNTR) was recently identified and the presence of the 2–3 alleles was found to be associated with a higher level of transcription, central nervous system serotonergic responsivity and impulsive aggression. A dinucleotide repeat in intron 2 of the gene (monoamine oxidase A-CAn) has been described previously, and is in linkage disequilibrium with the variable number of tandom repeats (VNTR). The aim of the study was to investigate, in a large sample, whether the monoamine oxidase A gene was involved in the susceptibility to suicidal behavior.MethodsWe genotyped 738 West European Caucasians, who had made suicide attempts, and 222 controls of the same ethnic origin, with no history of suicidal behavior. The two variants of the monoamine oxidase A gene have been tested.ResultsWe did not find any association between the two monoamine oxidase A gene variants and suicidal behavior. However, the frequency of the uVNTR 2–3 alleles was significantly higher in men who had attempted suicide by violent means than in men who had used non-violent means. The odds ratio for the uVNTR 2–3 alleles versus the uVNTR 1–4 alleles was 2.17 [95% confidence interval (1.08–4.35)]. Haplotypes did not allow strengthening the effect observed with the uVNTR.ConclusionThese results suggest that an excess of high-activity monoamine oxidase A gene promoter alleles may be associated with traits orienting suicidal behavior towards a violent act.