Direct water-phase synthesis of lead sulfide quantum dots encapsulated by β-lactoglobulin for in vivo second near infrared window imaging with reduced toxicity
Direct water-phase synthesis of lead sulfide quantum dots encapsulated by β-lactoglobulin for in vivo second near infrared window imaging with reduced toxicity
复制标题
直接水相合成β-乳球蛋白封装的硫化铅量子点，用于体内第二近红外窗口成像，毒性降低
DOI：
10.1039/c6cc00099a
复制
发表时间：
2016-01-01
影响因子：
4.9
通讯作者：
Chen, Shiyi
中科院分区：
文献类型：
--
作者：
Chen, Jun;Kong, Yifei;Chen, Shiyi
与可见光（400-700 nm）和NIR-I区域（700-900 nm）中的常规荧光成像相比，第二近红外窗口（NIR-II，1000-1400 nm）中的光学荧光成像提供了减少的光子散射、更深的组织穿透和更低的自发荧光。尽管具有出色的成像能力，但由于量子产率低、水溶性低和生物相容性不佳，目前的NIR-II探针尚未充分发挥其潜力。为了解决这些问题，我们在此报告了一种新的近红外-II荧光PbS量子点（QD），在水中使用β-乳球蛋白（LG）作为生物模板制造。LG-PbS量子点具有良好的介电常数、较高的量子产率和良好的生物相容性，因此适合于高分辨率的体内成像应用。
Compared to conventional fluorescence imaging in the visible (400-700 nm) and NIR-I regions (700-900 nm), optical fluorescence imaging in the second near infrared window (NIR-II, 1000-1400 nm) offers reduced photon scattering, deeper tissue penetration and lower auto-fluorescence. Despite excellent imaging capabilities, current NIR-II probes have not yet reached their full potential due to weak quantum yield, low water solubility and suboptimal biocompatibility. To address these problems, we report herein a new NIR-II fluorescent PbS quantum dots (QDs) that are fabricated in water using beta-lactoglobulin (LG) as a biological template. The LG-PbS QDs exhibit satisfactory dispersibility, relatively high quantum yield and favorable biocompatibility, and therefore are suitable for high-resolution in vivo imaging applications.